Pdgfrβ-Cre小鼠是一种用于研究血管平滑肌细胞和周细胞功能的基因工程小鼠品系。这些小鼠在Pdgfrβ(血小板衍生生长因子受体β)基因的控制下表达Cre重组酶。Pdgfrβ基因主要在血管平滑肌细胞和周细胞中表达,因此Pdgfrβ-Cre小鼠特别适用于在这些细胞类型中引入基因修饰。 Pdgfrβ-Cre小鼠的特点: 1. Cre-LoxP系统: Pdgfrβ...
Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins. Genesis 2016;Epub ahead of print.Ulvmar MH, Martinez-Corral I, Stanczuk L, Makinen T. Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins. Genesis 2016; 54:350 -358. Epub ...
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Pdgfrb-2A-tdTomato 品系名:C57BL/6Smoc-Pdgfrbem1(2A-tdTomato)Smoc 品系状态:在研 | 目录号:NM-KI-242616 Pdgfrb-KO 品系名:C57BL/6Smoc-Pdgfrbem1Smoc 品系状态:在研 | 目录号:NM-KO-242464 Pdgfrb-2A-Cre 品系名:C57BL/6Smoc-Pdgfrbem1(2A-Cre)Smoc 品系状态:在研 | 目录号:NM-KI-241533 hPD...
Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries. Genesis. 49:673-680. http://dx.doi.org/10.1002/dvg.20769Cuttler AS, LeClair RJ, Stohn JP, Wang Q, Sorenson CM, Liaw L et al. Characterization of Pdgfrb-Cre transgenic mice ...
Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethalityIP3 receptorCa2+ release channelGut motilityIntestinal pseudo-obstructionBackground Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+release channels located on the membrane of...
Isometric tension recording was used to measure the effects of IP(3)R1 deletion on muscle contraction.ResultsIn the mouse GI tract, Itpr1 gene deletion by Pdgfrb-Cre occurred in smooth muscle cells, enteric neurons, and interstitial cells of Cajal. pcR1KO mice developed impaired GI motility, ...
Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethalitydoi:10.1007/s00535-018-1522-7Background Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+release channels located on the membrane of endoplasmic reticulum, which have been...