An increase in mast cells is also a common feature of this disease, and there may be elevated serum tryptase with significant clinical overlap with systemic mastocytosis. Here, we present an unusual case of a myeloid neoplasm with PDGFRA rearrangement manifesting as a retromolar pad mass in a ...
In addition, 4 of the 10 imatinib-treated HES patients had gene rearrangement studies for a T-cell clone performed and one had a positive test. The latter patient did not respond, whereas 2 of the 3 with negative test results responded with a PR. Discussion We have examined the prevalence...
4 The karyotype of these cases, where known, did not reveal any rearrangement of chromosome 4q11-12, and rapid amplification of cDNA ends–polymerase chain reaction (RACE-PCR) of the PDGFRA gene in a subset of patients failed to identify any cytogenetically silent gene fusions2 Here, we ...
The FIP1L1-PDGFRA rearrangement results in constitutive activation of the tyrosine kinase PDGFRA. Neoplasms harboring this rearrangement are responsive to ... S Shah,S Loghavi,G Garcia-Manero,... - 《Journal of Hematology & Oncology》 被引量: 10发表: 2014年 加载更多来源...
Initial Symptom of Upper Respiratory Infection in Chronic Eosinophilic Leukemia with FIP1L1/PDGFRA Rearrangement: Recovery with Iimatinib This article intended to present and analyze a patient with factor interacting with PAPOLA and CPSF1/platelet-derived growth factor receptor 伪(FIP1L1/PDGF... K Li...
Myeloid/Lymphoid neoplasms with eosinophilia and PDGFRA, PDGFRB or FGFR1 Rearrangement, or with PCM1-JAK2 - Introduction 查宏斌,陈红梅,夏成青 更新时间:2018-04-23 13:10:00 概述: 这类克隆性血液系统肿瘤分为四组,其中有三个特异疾病组和一个临时实体,相互既有共同点也有不同之处。它们都存在融合基因...
Huang Q, Snyder DS, Chu P, Gaal KK, Chang KL, Weiss LM. PDGFRA rearrangement leading to hyper-eosinophilia, T-lymphoblastic lymphoma, myeloproliferative neoplasm and precursor B-cell acute lymphoblastic leukemia. Leukemia. 2011;25:371-5.
Our clinical NGS assay detected an unanticipated FIP1L1-PDGFRA rearrangement in his tumor. The patient was immediately placed on Imatinib therapy to which he responded, and remains in remission 10months after the rearrangement was initially detected....
Our clinical NGS assay detected an unanticipated FIP1L1-PDGFRA rearrangement in his tumor. The patient was immediately placed on Imatinib therapy to which he responded, and remains in remission 10聽months after the rearrangement was initially detected.Diana...
Complete response of mono- blastic myeloid sarcoma with FIP1L1-PDGFRA rearrangement to imatinib monotherapy[J]. British Journal of Haematology,2014.Srinivas U, Barwad A, Pubbaraju SV. Complete response of monoblastic myeloid sarcoma with FIP1L1-PDGFRA rearrangement to imatinib monotherapy [ J ]....