此类抗体可以用于调节细胞中或从细胞分泌的PDGF-CC活性,以研究PDGF-CC对细胞功能的影响,并且在某些实施方案中,用于治疗和/或预防与PDGF-C表达相关的疾病或状况。 发明背景 血小板衍生的生长因子(PDGF)对于正常组织生长和维持是重要的,并且还涉及多种病理状况,例如恶性肿瘤、动脉粥样硬化和纤维化。PDGF信号传导通过两种...
pdgf-c以潜伏的二聚体pdgf-cc从细胞分泌,并且已知在pdgf-cc能结合并激活其关联受体(pdgfr)前需要受调节的cub域的蛋白水解除去。认为活化的pdgf-cc,如pdgf-aa通过pdgfr-α同二聚体发出信号,尽管有人认为pdgf-cc和还有pdgf-dd两者也能够激活pdgfrα/β异二聚体复合物。pdgf-cc参与血管生成-许多恶性癌的形态学...
妊娠高血压患者胎盘组织VCAM及PDGF—AA表达及其意义
Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O et al. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl ...
In certain aspects, provided herein are RNA complexes (., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit ANGPT2 and/or PDGFB expression and are therefore useful for treating angiogenesis-associated diseases, such as cancer, AMD, and DME.リー,ドン-キ...
将抗原人pdgf-cc(peprotechaf-100-00c)以125ng/ml的浓度(25μl,在pbs,0.5%bsa和0.05%吐温中)固定在384孔微量滴定平板(thermoscientific,cat.no.464718)上。下述每个步骤之后是3次常规清洗(90μlpbs,0.5%bsa,0.05%吐温,以分散和抽吸进行):1)封闭步骤:使未结合的表面饱和(1小时,2%bsa);2)增加浓度的抗-...
PDGF的五种二聚形式是AA、BB、AB、CC 和DD,所述二聚形式通过对应单个PDGF单体的二硫连接而形成。PDGF配体通过与PDGF受体 (PDGFR)的相互作用而发挥其生物效应。PDGFR是由α(a)受体链(PDGFR‑α)和/或β(beta)受 体链(PDGF‑B)的异源二聚体或同源二聚体缔合构成的单程跨膜酪氨酸激酶受体。因此,活 性...
CONFIG_CC_HAS_ASM_INLINE=y CONFIG_IRQ_WORK=y CONFIG_BUILDTIME_TABLE_SORT=y CONFIG_THREAD_INFO_IN_TASK=y # # General setup # CONFIG_INIT_ENV_ARG_LIMIT=32 # CONFIG_COMPILE_TEST is not set CONFIG_LOCALVERSION="" # CONFIG_LOCALVERSION_AUTO is not set CONFIG_BUILD_SALT="" CONFIG_DEFAULT...
Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O et al. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl ...