pdgf-c以潜伏的二聚体pdgf-cc从细胞分泌,并且已知在pdgf-cc能结合并激活其关联受体(pdgfr)前需要受调节的cub域的蛋白水解除去。认为活化的pdgf-cc,如pdgf-aa通过pdgfr-α同二聚体发出信号,尽管有人认为pdgf-cc和还有pdgf-dd两者也能够激活pdgfrα/β异二聚体复合物。pdgf-cc参与血管生成-许多恶性癌的形态学...
此类抗体可以用于调节细胞中或从细胞分泌的PDGF-CC活性,以研究PDGF-CC对细胞功能的影响,并且在某些实施方案中,用于治疗和/或预防与PDGF-C表达相关的疾病或状况。 发明背景 血小板衍生的生长因子(PDGF)对于正常组织生长和维持是重要的,并且还涉及多种病理状况,例如恶性肿瘤、动脉粥样硬化和纤维化。PDGF信号传导通过两种...
将抗原人pdgf-cc(peprotechaf-100-00c)以125ng/ml的浓度(25μl,在pbs,0.5%bsa和0.05%吐温中)固定在384孔微量滴定平板(thermoscientific,cat.no.464718)上。下述每个步骤之后是3次常规清洗(90μlpbs,0.5%bsa,0.05%吐温,以分散和抽吸进行):1)封闭步骤:使未结合的表面饱和(1小时,2%bsa);2)增加浓度的抗-...
妊娠高血压患者胎盘组织VCAM及PDGF—AA表达及其意义
Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O et al. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl ...
Enzymatically active toxins and fragments thereof which can be used include diphtheria A chain, nonbinding active fragments of diphtheria toxin, exotoxin A chain (from Pseudomonas aeruginosa), ricin A chain, botulinum toxins, abrin A chain, modeccin A chain, alpha-sarcin, Aleurites fordii proteins...
结果健康对照组和关节炎组PDGF基因rs974819位点,FGF-2基因rs2922979位点上均检出GG型,GC型,CC型3种基因型,关节炎组携带CC型基因型及C等位基因占比显著高于健康对照组(PDGF:χ^(2)/P=41.726/<0.001,54.382/<0.001;FGF-2:χ^(2)/P=65.987/<0.001,88.988/<0.001),C等位基因可能是膝骨关节炎的易感基因....
In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit ANGPT2 and/or PDGFB expression and are therefore useful for treating angiogenesis-associated diseases, such as cancer, AMD, and DME.Dong-Ki Lee...
Targeting angiogenesis is a promising approach to the treatment of solid tumors and age-related macular degeneration (AMD). Inhibition of vascularization h... R Mabry,DG Gilbertson,A Frank,... - 《Mabs》 被引量: 63发表: 2010年 Emerging antiangiogenic therapies for non-small-cell lung cancer ...
In certain aspects, provided herein are RNA complexes (., asymmetric RNA complexes, such as asiRNAs or cell penetrating asiRNAs) that inhibit ANGPT2 and/or PDGFB expression and are therefore useful for treating angiogenesis-associated diseases, such as cancer, AMD, and DME.リー,ドン-キ...