不同PDGF亚型与其受体特异性结合会发挥不同生理功能,例如PDGF-AA、PDGF-BB、PDGF-AB和PDGF-CC与PDGFRαα结合激活PDGFRαα抑制成纤维细胞和平滑肌细胞的趋化性;同时PDGF-AA、PDGF-BB、PDGF-AB和PDGF-CC与PDGFRαα结合还调节C21类固醇...
We first detected alterations in PDGFR-β levels in the subchondral bone of humans with OA. Western blot results showed that the PDGFR-β level was remarkably elevated in the osteoarthritic part of the human subchondral bone compared with the relatively normal (RN) part (Fig.1a, b).7This ele...
产品名称: 重组小鼠血小板源性生长因子BB 产品又名: PDGFB细胞因子, PDGFB细胞因子 英文名称: Platelet-Derived Growth Factor Subunit B; PDGF Subunit B; PDGF-2; Platelet-Derived Growth Factor B Chain; Platelet-Derived Growth Factor Beta Polypeptide; Proto-Oncogene c-Sis; Becaplermin; PDGFB; PDGF2;...
Here we report that platelet derived growth factor bb (PDGFBB) promotes a significant increase in migration of PDGF receptor 伪 (PDGFR伪)-positive mesenchymal stem cells/pre-osteoblastic cells into artificial bone in vivo. Growth factors such as transforming growth factor beta (TGF尾) and ...
四个PDGF基因 (PDGFA、 PDGFB、PDGFC 和 PDGFD) 编辑 5 种具有生物活性的 PDGF 蛋白,它们由两个链的同源二聚体 (PDGF-AA、PDGF-BB、PDGF-CC、PDGF-DD) 或异源二聚体 (PDGF-AB) 组成。PDGF 具有高度保守的 8 个半胱氨酸残基结构域,称为PDGF/VEGF同源结构域。PDGFs 有两个同源的跨膜受体:PDGFRα和...
8. 计算:根据试剂盒提供的标准曲线,将各孔的光密度值转化为PDGF-BB浓度。如果样品经过稀释,还需考虑稀释倍数。 参考文献: 1. Wihlborg AK, et al. The role of PDGF-C and PDGFR-alpha signaling in adrenal cortex carcinogenesis. Oncogene. (2010) ...
PDGFR-α对PDGF-AA、PDGF-BB和PDGF-AB这三种形式来说是一种高亲和性受体。另一方面,PDGFR-β与PDGF-BB和PDGF-AB相互作用而不与PDGF-AA作用。 (1) PeproTech重组人PDGF-AA(Recombinant Human PDGF-AA)Cat#100-13A;AF-100-13A 分子量28.5kDa,二硫键连接两条A链(共250个氨基酸)的同源二聚体。
beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b antigen; CD140b; EC 2.7.10; EC 2.7.10.1; JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; PDGF-R-beta; platelet-derived growth factor receptor, beta polypeptide ...
This effect of baicalin is mediated, at least partly, through blockade of the PDGF receptor β (PDGFRβ)-extracellular signal-regulated ki- nase 1/2 (ERK1/2) signaling cascade. Results Baicalin inhibits PDGF-BB-induced proliferation of VSMCs Baicalin has been demonstrated as an active antitu...
level of phospho-PDGFR-β in LX-2 cells (Fig. 7) (P<0.05). Figure 5 Detection of the PDGF-BB expression in the LX-2 cells by ELISA. After stimulation with HBV particles for 12 h, or co-cultured with the HepG-control, HepG-s, HepG-x, HepG-c, HepG-e and HepG2.2.15 cell ...