[33] Hao Y, Dong X, Zhang M, et al. Effects of hyperbaric oxygen therapy on the expression levels of the inflammatory factors interleukin-12p40, macrophage inflammatory protein-1β, platelet-derived growth factor-BB, a...
The results presented suggest that IGF-1 and PDGF-bb are potent inhibitors of IL-1β-mediated activation of NF-κB and apoptosis in chondrocytes, may be mediated in part through suppression of Src/PI-3K/AKT pathway, which may contribute to their anti-inflammatory effects.Authors...
However, exposure to IL-4 prematurely inhibits osteogenesis of MSCs in vitro; furthermore, IL-4 overexpressing MSCs inhibit osteogenesis in vivo during the acute inflammatory period. Platelet-derived growth factor (PDGF)-BB has been shown to enhance osteogenesis of MSCs with a dose-dependent effect...
实验室检查的差异;分别进行以上分组的血浆PDGF-BB水平的比较;分析rs1800817位点、rs2285094位点基因型及等位基因频率在对照组、冠心病组、冠心病不同临床分型组及ACS患者不同病变支数组分布情况的差异;比较不同基因型与PDGF-BB血浆水平的关系,以及不同基因型与冠心病、冠心病不同临床分型及冠脉病变严重程度的...
anti-PDGFR-β antibody. The presence of FAK, TLN1, and PDGFR-β in these immunoprecipitates was evaluated with immunoblotting. Western blot analysis of FAK, TLN1, and VEGF in the BMECs treated with different PDGF-BB doses (0-300 ng·mL−1) (d) or for different times at 0 h–...
D. et al. Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases. Acta Pharmacol. Sin. 44, 1238–1251. https://doi.org/10.1038/s41401-022-01028-9 (2023). 21. Wang, H. et al. TIPE2 inhibits PDGF-BB-induced phenotype ...
The mechanism of benefit deriving from cell-based therapy, including the contribution of new cardiomyocytes, angiogenesis, anti-inflammatory actions, anti-fibrotic actions, anti-apoptotic actions, and other effects.29However, the mechanism through which these injected cells augment cardiac function has not...
S1b). In accordance with the results of the gel contraction assay, the HMrSV5 cells initially had a cobblestone shape, they became spindle-shaped 24 h after the addition of PDGF BB and TGF β1, respectively, moreover, addition of anti-human PDGF BB, TGF β1 neutralizing antibodies or...
Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting on syndesmophyte formation in AS are not well identified. We aimed to find the key AS-as
suggesting that H2O2induced early and late apoptosis. When MSCs were coincubated with 50 ng/ml PDGF-BB for 24 h, the percentage of apoptotic cells significantly decreased (P < 0.01 vs. H2O2-vehicle.). Taken together, these findings suggest that PDGF-BB induces the migratory and anti-apo...