[0014] 在另一方面,本发明提供了用于鉴别患有对PD3A调节应答的癌症的受试者的试剂 盒,所述试剂盒包含结合PDE3A的捕获试剂和/或结合SLFN12的捕获试剂。在一个实施方案 中,所述试剂盒包含结合PDE3A的捕获试剂和结合SLFN12的捕获试剂。 [0015] 在又一方面,本发明提供了用于在由于对PDE3A调节剂应答而预先选出的受...
However, the allosteric regulation in PDE2 occurs through cGMP binding to the GAFb domain rather than to the N-terminal GAFa domain seen in PDE5. Structural analysis of the PDE2A dimer and site-specific mutations revealed that the catalytic domain H-loop of the dimer partner occludes ...
The selectivity of compounds 1–25 against the selected major off-targets A2BR, A3R, PDE7A, PDE7B, and PDE9A, was predicted using PIDGIN at a threshold for binding greater than or equal to 0.8, and subsequently tested experimentally. It is noted here that the IC50 values were determined ...
The active site of PDE5 is placed in the center of the C-terminal helical bundle domain and it includes five subsites: while the metal-binding site (M site) and the core pocket (Q-pocket; lined by Gln817, Phe820, Val782, Tyr612) are common to most of the PDE family members, the...
The selectivity of compounds1–25against the selected major off-targets A2BR, A3R, PDE7A, PDE7B, and PDE9A, was predicted using PIDGIN at a threshold for binding greater than or equal to 0.8, and subsequently tested experimentally. It is noted here that the IC50values were determined for ...
cancers Article The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression Peter Dietrich 1,2, Claus Hellerbrand 1,3,* and Anja Bosserhoff 1,3 1 Institute of Biochemistry, Emil-Fischer-Zentrum, Friedrich-Alexander-University, ...