PDE-4 inhibitors: the use of molecular-cloning in the design and de- velopment of novel drugs. Drug Discov. Today 2:89-101.Hughes, B., Owens, R., Perry, M., Warrellow, G., Allen, R., 1997. PDE4 inhibitors: the use of molecular cloning in the design and develop- ment of ...
Phosphodiesterase-4 (PDE4) inhibitors belong to a class of medications known as disease-modifying anti-rheumatic drugs (DMARDs). PDE4 inhibitors are prescribed to reduce inflammation and slow down disease progression inpsoriasis, an inflammatory skin condition that can also lead to joint inflammation ...
Subtype-Selective PDE4 Inhibitors Provide Opportunities for Nonamyloid Therapies for AD There is a need for the discovery of nonamyloid based therapeutics for AD. The two classes of approved drugs—acetylcholine esterase inhibitors, which address the loss of acetylcholine due to cholinergic neuron death...
WOLDA S L: "PDE4 INHIBITORS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE" EMERGING DRUGS, ASHLEY PUBLICATIONS, LONDON, GB, vol. 5, no. 3, 2000, pages 309-319, XP008016335 ISSN: 1361-9195 cited in the applicationWOLDA S L: "PDE4 INHIBITORS AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE" EMERGING ...
[12]Manning CD, Burman M, Christensen SB, Cieslinski LB, Essayan DM, Grous M, et al. Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Br ...
Drugs associated with PDE4 x PDE7A YM-393059 Target PDE4 x PDE7A Mechanism PDE4 inhibitors[+1] Active Org. Astellas Pharma, Inc. Originator Org. Astellas Pharma, Inc. Active Indication Autoimmune Diseases Inactive Indication- Drug Highest PhasePreclinical ...
Measurement of locomotor activity in mice treated with A-33 and D159687. The observed "antidepressant-like" effects of drugs can sometimes be interpreted as a general stimulation of the central nervous system of an individual. And in order to assess if the PDE4B and PDE4D inhibitors had...
PDE4 has thus emerged as a potential therapeutic target for the treatment of substance abuse and substance use disorders (Olsen and Liu, 2016; Wen et al, 2015). The mechanisms by which PDE4 inhibitors reduce behavioral effects of drugs of abuse remain poorly under- stood. Presynaptic Gi/o-...
PrGenSelective inhibitors of the isoenzyme phosphodiesterase 4 (PDE 4) have attracted increased interest in the last few years as potential drugs for the treatment of allergic diseases such as asthma l,2 .doi:10.1007/978-1-4615-4141-7_93E. E. Polymeropoulos...
Despite the challenges and complications that have been encountered during the development of PDE4 inhibitors, these drugs may provide a genuinely novel class of anti-inflammatory agents, and there are several compounds in development that could fulfill that promise. 展开 关键词:...