2024年9月16日,中南大学彭聪及陈湘共同通讯在Biomaterials上在线发表题为“Eravacycline improves the efficacy of anti-PD1 immunotherapy via AP1/CCL5 mediated M1 macrophage polarization in melanoma”的研究论文。越来越多的证据表明,抗...
先来说说表达,表达PDL1的细胞很多,包括跟T/B等免疫细胞和很多其他的组织的细胞,部分癌细胞会高表达PDL1,这也是使用PD1和PDL1的抗体的基础;PDL2的表达谱很窄,肿瘤中PDL2的高表达也很少报道,这应该是为什么没有人用PDL2抗体抗肿瘤的主要原因。但是,PDL2会在DC细胞...
超进展的机理说啥的都有：抗体使得macrophage朝着M2极化；anti-PD1使得Treg细胞增殖等等。我觉得很有可能...
3. Encouse B Golden , Arpit Chhabra , Abraham Chachoua, et al. Local Radiotherapy and Granulocyte-Macrophage Colony-Stimulating Factor to Generate Abscopal Responses in Patients With Metastatic Solid Tumours: A Proof-Of-Principle Trial. Lancet Oncol 2015;16(7):795-803...
超进展的机理说啥的都有:抗体使得macrophage朝着M2极化;anti-PD1使得Treg细胞增殖等等。我觉得很有可能都对,也很符合我肿瘤微环境那篇文章里的理论,IO药物的药效和进入肿瘤那一刻的初始状态高度相关。虽然不知道机理,但超进展在临床上是确定的现象,早发现早换药。
6. Xiong, H., Mittman, S., Rodriguez, R., Moskalenko, M., Pacheco-Sanchez, P., Yang, Y., Nickles, D., and Cubas, R. (2019). Anti–PD-L1 treatment results in functional remodeling of the macrophage compartment. Cancer Res. 79, 1493–1506. https://doi.org/10.1158/0008-5472....
3. Encouse B Golden , Arpit Chhabra , Abraham Chachoua, et al. Local Radiotherapy and Granulocyte-Macrophage Colony-Stimulating Factor to Generate Abscopal Responses in Patients With Metastatic Solid Tumours: A Proof-Of-Principle Trial. Lancet Oncol 2015;16(7):795-803...
但是,PDL2会在DC细胞和macrophage上诱导表达,尤其是在肺部的DC上表达,有研究表明PDL2在诱导肺部免疫耐受中起着很重要的作用: 这是2010年发表在《Mucosal Immunol》上关于PDL2在肺部气道炎症(airway inflammation)的研究结果,比较了PDL1和PDL2敲除的小鼠诱发AHR(免疫相关的肺炎模型,或者呼吸道过敏)的不同,很明显的...
原名:Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies 译名:非小细胞肺癌巨噬细胞浸润的空间转录组学揭示了抗PD1/PD-L1抗体敏感性和抗性的决定因素 期刊:Journal for ImmunoTherapy of Cancer IF:12.4...
This interaction leads to the reprogramming of macrophage metabolism, shifting from glycolysis to mitochondrial oxidative phosphorylation via the Erk-dependent pathway in ALI. Importantly, we have reproduced the PDL1鈥揚D1 effects of ABs on metabolic switch using alveolar macrophages from patients with ...