在某些情况下,IgG4Fc结构域具有以下序 列: CPPCPAPEFEGGPSVFLFPPKPKDTLMetISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQ FQSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMetTKNQVSLTCLV KGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMetHEALHNHYTQKSLSL SLGK(SEQ ID NO:23) [...
[0157] (a)lalidwx1x2dkx3ysx4slksrl(seq id no.:175),其中: [0158] x1:a或d或y [0159] x2:d或g [0160] x3:r或s或y [0161] x4:p或t; [0162] (b)igx1iyhsgx2tyyx3pslksrv(seq id no.:176),其中: [0163] x1:d或e [0164] x2:n或s [0165] x3:n或s;以及 [0166] (c)vsx1...
[0157] (a)lalidwx1x2dkx3ysx4slksrl(seq id no.:175),其中: [0158] x1:a或d或y [0159] x2:d或g [0160] x3:r或s或y [0161] x4:p或t; [0162] (b)igx1iyhsgx2tyyx3pslksrv(seq id no.:176),其中: [0163] x1:d或e [0164] x2:n或s [0165] x3:n或s;以及 [0166] (c)vsx1...
YKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHE ALHNHYTQKSLSLSLGK。其中,MEFGLSWLFLVAILKGVQC为信号肽。 [0137]QD163(SEQ ID NO:13) [0138] 其中,双下划线部分是恒定区序列。 [0139]QD164(SEQ ID NO:14) [0140] [0141] 其中,双下划线 部分是恒定区序列。 [0142]QD245(SEQ ID NO:15) [0143] [0144...
(seqidno:161)qvqlkqsgpglvqpsqslsitctvsgfsltnygvhwvrqspgkglewlgviwsggntdyntpftsrlsinkdnsksqvffkmnslqsndtaiyycaraltyydyefaywgqgtlvtvsacdr1(seqidno:251):nygvhcdr2(seqidno:252):iwsggntdyncdr3(seqidno:253):altyydyefay>西妥昔单抗_lc(seqidno:162)dilltqspvilsvspgervsfscrasqsigtnihwyqq...
animals have been were approved by the Italian Ministry of Health (Authorizations 213/2016 PR) and have been done in accordance with the applicable Italian laws (D.L.vo 26/14 and following amendments), the Institutional Animal Care and Use Committee of CEINGE and Allevamenti Plaisant SRL. ...
在初治的、表达程序性细胞死亡蛋白配体1(肿瘤比例分数≥50%)的18岁或以上转移性非小细胞肺癌男性和女性受试者:比较帕博利珠单抗联合戈沙妥珠单抗治疗与帕博利珠单抗单药治疗的由盲态独立中心审查根据RECIST 1.1评估的无进展生存期和总生存期。 2、试验设计 ...
LAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSC...
(g)LALIDWX1X2DKX3YSX4SLKSRL(SEQ ID NO.:175),其中: X1:A或D或Y X2:D或G X3:R或S或Y X4:P或T; (h)IGX1IYHSGX2TYYX3PSLKSRV(SEQ ID NO.:176),其中: X1:D或E X2:N或S X3:N或S;以及 (i)VSX1ISGX2GX3X4TYYADSVKGRF(SEQ ID NO.:177),其中: X1:A或G或S或V或Y X2:A或D...
[0119]QITLKESGPTLVKPTQTLTLTCTVSGFSLSTYGVHWIRQPPGKALEWLGVIWRGVTTDYNAAFMSRL TITKDNSKNQVVLTMNNMDPVDTATYYCARLGFYAMDYWGQGTLVTVSS(SEQ ID NO:13); [0120]DIQMTQSPSSLSASVGDRVTITCKASQSVSNDVAWYQQKPGKAPKLLIYYAANRYTGVPDRFSGSGY GTDFTFTISSLQPEDIATYFCQQDYTSPYTFGQGTKLEIK(SEQ ID NO:14); [0121]EVQLVESGG...