[5] Tumor Area Positivity (TAP) score of programmed death-ligand 1 (PD-L1): a novel visual estimation method for combined tumor cell and immune cell scoring. Diagn Pathol. 2023 Apr 19;18(1):48. [6] 默沙东中国官网信息. https:/...
[5] Tumor Area Positivity (TAP) score of programmed death-ligand 1 (PD-L1): a novel visual estimation method for combined tumor cell and immune cell scoring. Diagn Pathol. 2023 Apr 19;18(1):48. [6] 默沙东中国官网信息. https://www.msdchina.com.cn/search/index.html?s=%E5%B8%95%E5...
为任何强度 PD-L1 膜和胞浆染色肿瘤相关免疫细胞占所有肿瘤相关免疫细胞百分比。 TAP(Tumor Area Positivity Score)指肿瘤区域阳性评分。为通过视觉图像(细胞面积法)评估 PD-L1 染色的肿瘤细胞和免疫细胞的面积占所有肿瘤面积(肿瘤细胞和相关基质)的百分比。 TP...
[3] Golesworthy B, Wang Y, Tanti A, et al. Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma. Front Oncol. 2022 Apr 25;12:860767. [4] Cerniglia M, Xiu J, Grothey A, et al. Association of Homologous Recomb...
目前,食管癌免疫治疗临床研究中使用的PD-L1评分体系包括CPS、TPS和PD-L1阳性肿瘤面积(tumor area positivity, TAP)评分。CPS是指阳性活肿瘤细胞(任何强度的部分或完全膜染色)及阳性淋巴细胞、巨噬细胞(任何强度的细胞膜或细胞质染色)占所有活肿瘤细胞的百分比,再乘以100,结果采用0～100数值来表示(图2)。TPS是指肿...
PD‐L1 CPS ≥5 was observed in 11/11 (100%) patients with EBV positivity, 9/12 (75%) patients with MSI, and 17/33 (52%) patients with high TMB. For the 108 patients who received ICI therapy, CPS ≥5 was the only predictor significantly associated with survival in mult...
TPS:肿瘤细胞阳性比例分数(Tumor Proportion Score);CPS:(肿瘤细胞&免疫细胞)阳性联合分数(Combined Positive Score)TC:任何染色强度,肿瘤区域中肿瘤细胞染色的百分比(Tumor Cell)IC:肿瘤区域中的染色阳性免疫细胞所占面积的百分比(Immune Cell)TAP:肿瘤区域阳性评分(Tumor Area Positivity Score),通过视觉图像(细胞面积法...
PD-L1 检测报告推荐使用联合阳性分数（combined positive seore，CPS）或者肿瘤区域阳性（tumor area positivity，TAP）评分。CPS=PD-L1 染色细胞（包括肿瘤细胞、巨噬细胞与淋巴细胞）的总数/镜下肿瘤细胞总数（×100）TAP=PD-L1 阳性的肿瘤细胞与肿瘤相关免疫细胞（包括巨噬细胞与淋巴细胞）/肿瘤总面积×100%。举...
PD-L1 positivity on TC did not show any significant impact on either RFS or OS compared with PD-L1 negativity on TC (5-year RFS: 72.4% vs. 65.6%, P = 0.206; 5-year OS: 80.1% vs. 77.7%, P = 0.317) (Fig. 4A,B). In contrast, patients with PD-L1-positive...
[3] Golesworthy B, Wang Y, Tanti A, et al. Intra-Tumoral CD8+ T-Cell Infiltration and PD-L1 Positivity in Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma. Front Oncol. 2022 Apr 25;12:860767. [4] ...