The Pd-catalyzed transfer of difluorocarbene is described to realize the coupling reaction of boronic acids with difluorocarbene to give (difluoromethyl)arenes and -olefins. Mechanistic investigations reveal that the Pd═CF2 complex is an important intermediate for this transformation. This complex ...
Subsequently, alkylpalladium species were formed with carbene intermediate generated from the diazo compound. Finally, β-H elimination allowed for the synthesis of the desired product and the regeneration of Pd(0) [43]. In situ-produced vinyl fluorosulfate intermediates were coupled with electron-...
Recently the mechanism of the Pd-catalyzed asymmetric hydrogenation of unprotected indoles has been studied in detail40. There are two possible reaction pathways, inner-sphere hydrogenation with direct coordination of the C = N bond to Pd, and out-of-sphere hydrogenation with direct involvement ...
Summary of main observation and conclusion: Outstanding accomplishments have been achieved in the chemistry of difluorocarbene, but transition‐ metal‐catalyzed transfer of difluorocarbene for coupling remains a challenging task. Herein, we describe a Pd‐catalyzed coupling of difluorocarbene with two ...
catalyzedSummary of main observation and conclusion Outstanding accomplishments have been achieved in the chemistry of difluorocarbene,but transitionmetal-catalyzed transfer of difluorocarbene for coupling remains a challenging task.Herein,we describe a Pd-catalyzed coupling of difluorocarbene with two aryl...
A series of aryl benzoates were synthesized in up to 84 % yield via difluorocarbene transfer carbonylation. It is devoted to acquiring the targeted products by construction of new CC, C=O and CO bonds in a one‐pot, one‐step process. The feature of this method includes the ...