大部分联用的ORR和PD-1/L1单药不相上下,好在联用可以让PD-1/L1耐受或者复发的病人受益,药企有理由继续推进。 COM902(TIGIT)和COM701(PVRIG)联用的临床数据是近几年来最值得期待的,他们有可能打破和PD-1/L1联用的传统。 Siglec-15独木难支,Nextcure孤立无援 2019年陈列平在nature medicine发表Siglec-15新一...
ALL protein lysate or Wilms' Tumor 1 peptide could significantly increase the expression of TIGIT in ALL, but not healthy control T cells. Compared to TIGIT- cells, the TIGIT+ cells presented significantly higher PD-1 and Tim-3 expression directly ex vivo, and significantly lower IL-2, IFN-...
tim-3.Programmed cell death 1 ligand 1), programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3, lymphocyte activation gene-3, and T-cell immunoglobulin and ITIM domain (TIGIT) are considered major immune co-...
PD-1CTLA-4TIGITLAG-3TIM-3PERIPHERAL-BLOODPROGNOSTIC VALUEHigh expression of immune checkpoint receptors (ICRs) in the tumor microenvironment regulates the anti-tumor response. In this study, the differential expressions of ICRs on tumor-infiltrating lymphocytes (TILs) in patients with early-stage ...