Patients were divided into CRAFITY 0 score (n=32), CRAFITY 1 score (n=31), and CRAFITY 2 score (n=22), respectively. The primary outcomes were overall survival (OS) and progression-free survival (PFS), and the secondary outcomes included tumor response rate and treatment-related ...
Chen S, Crabill GA, Pritchard TS, McMiller TL, Wei P, Pardoll DM, et al. Mechanisms regulating PD-L1 expression on tumor and immune cells. J Immunother Cancer. 2019;7(1):305. Article PubMed PubMed Central Google Scholar Yi M, Niu M, Xu L, Luo S, Wu K. Regulation of PD-L1...
并再次进行抗PD-1治疗;② 治疗安全性良好,3名患者产生临床应答(2名部分应答、1名完全应答);③ 粪菌移植(FMT)改变了受体的肠道菌群,增加利于免疫治疗的韦荣球菌科、减少促免疫耐受的两歧双歧杆菌,但未鉴定出与临床应答显著相关的细菌类群和代谢功能;④ FMT治疗与肠道和肿瘤微环境中的免疫细胞浸润...
Dávid Bajusz 7, Diana Kruhl 8, Eva Böttcher‑Friebertshäuser 8 & Erzsébet Pászti‑Gere 1* Certain corona- and influenza viruses utilize type II transmembrane serine proteases for cell entry, making these enzymes potential drug targets for the treatment of viral resp...
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Dávid Bajusz 7, Diana Kruhl 8, Eva Böttcher‑Friebertshäuser 8 & Erzsébet Pászti‑Gere 1* Certain corona- and influenza viruses utilize type II transmembrane serine proteases for cell entry, making these enzymes potential drug targets for the treatment of viral resp...
EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 融合蛋白BY31.3(κ,IgG2)的第二亚基(BY31.3H)核苷酸序列(SEQ ID NO:82): ...
Chen S, Crabill GA, Pritchard TS et al (2019) Mechanisms regulating PD-L1 expression on tumor and immune cells. J Immunother Cancer 7:305 ArticleGoogle Scholar Cimino-Mathews A (2021) Novel uses of immunohistochemistry in breast pathology: interpretation and pitfalls. Mod Pathol 34(Suppl 1):...
30. A method for enhancing or inhibiting an immune response in a mammal comprising administering the PD-L1 binding agent of claim 1 or conjugate comprising same, or a composition comprising the PD-L1 binding agent or conjugate comprising same, to the mammal. 31. The method of claim 30, wher...