并再次进行抗PD-1治疗;② 治疗安全性良好,3名患者产生临床应答(2名部分应答、1名完全应答);③ 粪菌移植(FMT)改变了受体的肠道菌群,增加利于免疫治疗的韦荣球菌科、减少促免疫耐受的两歧双歧杆菌,但未鉴定出与临床应答显著相关的细菌类群和代谢功能;④ FMT治疗与肠道和肿瘤微环境中的免疫细胞浸润...
aFifteen biomarkers are selected for differentiating PD and NPD patients treated with the anti-PD-1 monotherapy using the ROC curves and the corresponding AUC values. The data reveals that baseline blood SAA had the highest value (AUC: 0.848) in predicting tumor response under the RECIST (v.1.1...
Tshoefscerystsrtaailnlastatriceeadsimstoalrltcioonntcraiubusetdiobnytomtahgenoevtiecrasalltumraagtinoent.oTsthreicytfioolnlowwhaicnhinarviesresferpormopcolarstsioicna-l ality to the elastic constant C′, which causes a peak to occur at the martensitic transformation temperature where the ...
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Similarly, commonly employed laboratory parameters such as baseline transforming growth factor beta, lactate dehydrogenase, dynamic changes in alpha-fetoprotein (AFP) and abnormal prothrombin, CRAFITY score (composed of C-reactive protein and AFP), and immune adverse events have...
本发明属于肿瘤治疗和分子免疫学领域,涉及一种包含抗CTLA4‑抗PD‑1双特异性抗体和西奥罗尼的药物组合。具体地,所述的药物组合,其包含西奥罗尼或其可药用盐或其晶型,以及至少一种抗CTLA4‑抗PD‑1双特异性抗体。本发明还涉及所述药物组合的用途。本发明的药物组合具有良好的抗肿瘤效果。
the application of lncRNAs as immunotherapy targets could be a useful strategy for enhancing treatment efficiency in cancer patients. Although lncRNAs and circRNAs play a pivotal role in the immune response by targeting PD-1/PD-L1, several issues need to be addressed to fully understand the functio...
In [20], a fuzzy PID controller to achieve a zero overshoot step response has been presented. The CRA and CDM approaches have been employed to design non-overshooting PID controllers for some real plants [21–23]. In [24], a mod- ified version of the PID controller, called I+PD con-...
(D) XRD pattern of (rFABGiug)O@uA/rPGmedC4/pC.Ee ro,(oFA(mfe))2eONetsry4ti/rqcrauGrdiesOisotp/lp/GoBlnoCSstAsEe o,/aa(ftdnt−h)ti ea0-nE.E3tSI iVTS-E/fvASosTr.uS/e@ACaPcuEhd@f/ioCPmrdomt/FhCeoeo2bOGFileC4i/z2rEOeGd4wO/srittG/ehGpOdCo/iEffGf(eCiarn)eE1...
Double strand breaks (DDSB) that has been well-recognized as the most lethal type of damage induced by the ionizing radiation, is a major indicator of RT efficacy29. Then, the effect of HMP on enhancing radiation response was evaluated by using a specific marker-γ-H2AX staining. As expected...