Means were compared using Mann-Whitney U test. Correlation was estimated using Pearson's coefficients. Overall survival (OS) was assessed using Kaplan鈥揗eier curves and Cox proportional hazard models. A two-side
All data presented are means + /− SEM and show individual data points. Source data Extended Data Fig. 9 Primary T. gondii infection depletes eTreg cell populations in both C57BL/6 and hemizygous Foxp3cre x PD-1wt/flox mice, while eTreg cells in homozygous Foxp3cre x PD-1flox/...
Therefore, to assess the reliability of PD-L1 scoring by digital images compared with that of the standard microscopic assessment on glass slides, we used two statistical methods, with the means of scores by both methods used for each assay. Both Pearson correlation and Bolt and Altman’s ...
The probability of DCR superiority in the VEX cohort and the DDP cohort were 97.1% and 98.3%, respectively (Extended Data Table1). Among the five treatment cohorts, the VEX and DDP cohorts had the highest DCR of 69.7% (95% credible interval (CI) 51.7–85.9%) and 73.7% (95% CI 56.1...
The PFS at 6 months was 35.7% (80% CI 26.4% to 45.1%), which means that this trial met the primary endpoint. The median PFS and OS were 4.0 (95% CI 2.3-5.7) months (Figure 2A) and 10.9 (95% CI 9.9-16.0) months (Figure 2B), respectively. Of 34 patients with baseline target ...
PFS, 0 means progression free, 1 means progression or death; OS: 0 means alive, 1 means death. c, Representative fluorescence images showing CPT1A and PD-L1 expression in patients with distinct therapy responses. d, Heatmap illustrating a significant negative correlation between CPT1A and PD-...
center Phase 3 clinical study on ES-SCLC has been carried out in many countries in Asia and Europe, with more than 580 subjects worldwide. It is believed that by means of international multi-center clinical data, se...
An in-depth investigation into the mechanisms underpinning resistance to PD-1/PD-L1 inhibitors could catalyse the emergence of novel immunotherapeutic approaches or enhance the effectiveness of existing treatments. This might offer a means to mitigate progression of the disease and secure more enduring ...
Each bar in the boxplot at a fixed threshold represents the impact on MSE when removing the top m% of cells. (k means the selection of top cells with the largest area, t% means proportion of brown area in a single cell area, m% means the exclusion of the largest cells based on ...
(K) Percentage of splenic PD-L1+MHC-II+ cDC1s and cDC2s in WT and Jak1ΔDC mice 8 days after EAE induction; n = 5 per genotype. The data are represented as means ± SEMs of biologically independent animals. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗...