Bu X, Juneja VR, Reynolds CG, Mahoney KM, Bu MT, McGuire KA, Maleri S, Hua P, Zhu B, Klein SR, Greenfield EA, Armand P, Ritz J, Sharpe AH, Freeman GJ. Monitoring PD-1 Phosphorylation to Evaluate PD-1 Signaling during Antitumor Immune Responses. Cancer Immunol Res. 2021;9(12):...
A specific peptide epitope of the antigen has to be displayed on the major histocompatibility complex (MHC) of an antigen-presenting cell (APC), and it has to form a complex with the T-cell receptor on T cells to become activated. The second signal resulting from the interaction of co-...
In the case of palladocycle 2b, the pyridine units form parallel-displaced stacking interactions (with the interplane angle of 0° and the inter-centroid and shift distances of 3.7162(6) and 1.720(13) Å, respectively) that pack the anions into centrosymmetric dimers; those are held ...
Download: Download full-size image Fig. 1. T-cell inhibition in cancers can be mediated by the PD-1/PD-L axis and disrupted by PD-1/PD-L1 blockade therapy. Left panel: PD-L on malignant, stromal and/or immune cells within the TME can engage PD-1 expressed on infiltrating T-cells....
Soluble PD-L1 (sPD-L1) is the soluble form of the PD-L1 protein produced by tumor cells or other immune cells. It binds primarily to extracellular vesicles (exosomal PD-L1) or is expressed on the surface of circulating tumor cells (CTCs PD-L1). It can also exist in different forms, ...
(3ka), thiophenyl (3la), or indolyl (3ma)—had little influence on the reaction outcome, the corresponding α-alkenyl, α-alkyl α-AAs were obtained with excellent enantioselectivities. An alkyl-substituted substrate (R1 = cyclohexyl) furnished3nain 63% yield, albeit with a reduced ee...
Undeniably, cancer immunotherapies have expanded the spectrum of cancer treatment, however, some patients do not respond to immunotherapies. This scenario is no different for lung cancer, whose two main types, non-small cell lung cancer (NSCLC) and small
X-ray diffraction (XRD) analysis was performed on a Bruker D8-ADVANCE diffractometer with Cu Ka radiation at a wavelength of l 5 0.15418 nm. Transmission electron microscopy (TEM, JEOL JEM-2100) was used to investigate the morphology of samples. The crystalline properties of Pd/RGO were ...
Full size image PD-L1 high WJ-MSCs have stronger immunomodulatory capacity than PD-L1 low WJ-MSCs Next, we assessed our proposal that the immunomodulatory capacity of WJ-MSCs could be predicted by single gene expression levels. We observed variable expression of PD-L1, which encoded an importa...
Hofmeyer KA, Jeon H, Zang X. The PD-1/PD-L1 (B7-H1) pathway in chronic infection-Induced cytotoxic T lymphocyte exhaustion. J Biomed Biotechnol. 11:2011. Su L, Guo W, Lou L, Nie S, Zhang Q, Liu Y, Chang Y, Zhang X, Li Y, Shen H. EGFR-ERK pathway regulates CSN6 to contr...