standard treatments, including being relapsed or refractory to prior anti-PD-1 or anti-PD-L1 treatment; (for phase 1; part A and selected phase 2a cohorts) presented with biopsy-accessible tumour for serial bio
Full size image The co-culture of exosomes derived from UMSC/miR-124-PD-1 has the potential to induce apoptosis in GBM cells Furthermore, we isolated exosomes from both wild-type UMSCs and UMSCs gene-modified with various vectors. The median size of UMSC/miR-124-PD-1 derived exosomes mea...
Undeniably, cancer immunotherapies have expanded the spectrum of cancer treatment, however, some patients do not respond to immunotherapies. This scenario is no different for lung cancer, whose two main types, non-small cell lung cancer (NSCLC) and small
Full size image Discussion Cellular, or adoptive immunotherapy, constitutes the fourth pillar of cancer immunotherapy following surgery, radiation, and chemotherapy by harnessing the immune system’s capacity to eradicate tumors. CAR T-cell therapy has made substantial advancements in certain cancer treatme...
Notably, the development of anti-TGFβ × PD-L1 BsAb represents a groundbreaking approach to simul- taneously target multiple immunosuppressive pathways within the TME, thereby unleashing the full potential of the immune system against cancer. It is noteworthy that the dual role of TGFβ in ...
26. McLaughlin J, Han G, Schalper KA, Carvajal-Hausdorf D, Pelekanou V, Rehman J, et al. Quantitative assessment of the heterogeneity of PD-L1 expression in non- small-cell lung cancer. JAMA Oncol. 2016;2:46–54. 27. Li M, Li A, Zhou S, Xu Y, Xiao Y, Bi R, et al. ...
Download: Download full-size image Scheme 14. The Sonogashira reactions by Cu complexes of pincer N-heterocyclic carbenes. Very recently, Kapdi et al. reported a highly efficient Cu/carbazole-based N-heterocyclic carbene catalytic system for the Sonogashira reactions of synthetically beneficial nucleosid...
Rampai MM, Mtshali CB, Seroka NS et al (2024) Hydrogen production, storage, and transportation: recent advances. RSC Adv 14:6699–6718 Article CAS PubMed PubMed Central Google Scholar Ondrejka P, Mikolášek M (2023) Thin films and coatings for energy storage and conversion: from supercap...
Download: Download full-size image Fig. 1. T-cell inhibition in cancers can be mediated by the PD-1/PD-L axis and disrupted by PD-1/PD-L1 blockade therapy. Left panel: PD-L on malignant, stromal and/or immune cells within the TME can engage PD-1 expressed on infiltrating T-cells....
Our hypothesis is that gait impairments in PD-FOG patients may be preserved in some form and to some extent during the “interictal” period. The term "interictal" period in the context of FOG refers to the intervals between episodic FOG events, during which patients do not experience an ac...