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After incubation in a reservoir solution containing 20% (v/v) glycerol crystals were flash-cooled in liquid nitrogen. The diffraction data were collected at Shanghai Synchrotron Radiation Facility BL17U, and all data were processed with HKL2000 (ref.49). The complex structure was solved by molec...
All mice used for the present study were C57BL/6J mice of female (6–8 weeks old). Animal experiments were approved by Institutional Animal Care and Use Committee (IACUC) of Crown Bioscience (Taicang) Inc. The approval number is AN-1803-13-502. Expression of human PD-1 for immunization ...
Cancer-associated fibroblasts (CAFs) are one of the abundant cell types in the desmoplastic stroma, which is the major source of extracellular matrix (ECM) within the tumor microenvironment (TME)12. Emerging evidence indicates that the dense collagen matrix confers resistance to anti-PDAC therapies13...