免疫治疗是如今十分热门的癌症疗法,其中抗程序细胞死亡蛋白1(PD-1)及其配体(PD-L1)抑制剂更是获得了多个肿瘤诊疗指南的推荐,但其引发的不良反应也受人关注,王懿春教授介绍了免疫治疗所引起的肺炎以及细胞因子释放综合征的病人管理策略。 免疫检查点...
This Review is focused on the role of PD-1–PD-L1 blockade in unleashing host antitumour immune responses against various B-cell lymphomas, and summarizes the clinical studies of this approach performed to date.This is a preview of subscription content, log in via an institution to check ...
This systematic review and meta-analysis describes the various adverse events associated with PD-1 and PD-L1 inhibitor drugs reported in clinical trials
K. Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer-review of current data. Oral Oncol. 51, 12–15 (2015). 4. Kim, J. W. & Eder, J. P. Prospects for targeting PD-1 and PD-L1 in various tumor types. Oncology 28 Suppl 3, 15...
Hui Sunhttps://ror.org/04ct4d772grid.263826.b0000 0004 1761 0489Department of Oncology, The Affiliated Nanjing Pukou People’s Hospital of Jiangsu Health Vocational College, Nanjing Pukou People’s HospitalLiangjiang Hospital Southeast University 211800 Nanjing ChinaYue-Yu Fang...
Inter. 5, 1761–1767 (2013). Acknowledgements This study was supported by the National Natural Science Foundation of China (No. 21175057, 21375047, 21377046), the Science and Technology Plan Project of Jinan (No. 201307010), the Natural Science Foundation of Shandong Province (No. ZR2013BL...
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Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CC
11. Gray, D. L. Sonogashira Reaction. In Name Reactions for Homologations-Part II; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2009, pp 100-133. (Review). 12. Shigeta, M.; Watanabe, J.; Konishi, G.-i. Tetrahedron Lett. 2013, 54, 1761-1764. ...
from the National Institutes of Health (NIH) (1R01CA176111A1; 1R21CA215910-01; R21CA255837-01), the Melanoma Research Alliance (MRA), and the V Foundation for Cancer Research. Additional funding was provided by the MRA (to Y.W., S.L., Z.Y., and G.M.), Jonsson Comprehensive ...