Reporting summary Further information on research design is availablein the Nature Research Reporting Summary linked to this article. Data availability RNA-sequencing data that support the findings ofthis study have been deposited in NCBI with the accession code PRJNA609233. The remainingdata are availa...
Reporting Summary Supplementary Tables 1–5. Source data Source Data Fig. 3 Unprocessed Western Blots for Fig. 3f Source Data Fig. 3 Raw data for d, e. Source Data Fig. 5 Raw data for a-c, f, g. Source Data Fig. 7 Raw data for a-c Source Data Extended Data Fig. 3 Unprocessed...
In summary, a semi-mechanism-based PK/PD model was developed and evaluated based on preclinical data to quantita- tively describe the antitumor efficacy of DEX combined with SUL and their synergistic effect in drug-resistant breast cancer. DEX inhibited tumor natural growth, and SUL significantly ...
In summary, we revealed a molecular mechanism of immunosuppression in CRC cells—through CSN5-regulated PD-L1 stabilization, which was critical for the escape of cancer cells from immune surveillance. Importantly, C-15, an inhibitor of CSN5, significantly impaired PD-L1 stabilization in CRC cells...
4. Conclusions In summary, we have successfully developed an efficient method to synthesize various bis β-N,S-glycosyl quinolin-2-ones via the palladium-catalyzed coupling of α- or β-mono-, di-, and poly-thiosugar derivatives with α- or β-3-iodo-N-glycosylquinolin-2-ones. Efforts ...
Summary Cytotoxin-associated gene A (CagA) of Helicobacter pylori (Hp) may promote immune evasion of Hp-infected gastric cancer (GC), but potential mechanisms are still under explored. In this study, the positive rates of CagA and PD-L1 protein in tumor tissues and the high level of exosomal...
In summary, experimental results confirm that the design of XmAb24306 confers higher systemic exposure in cynos that translates to greater lymphocyte expansion in response to single or Q2W repeat dosing, compared to wild-type IL-15 or fusion-proteins thereof. Abundance and activity of immune effect...
of tested qualified/ positive animals % (rate/%) 检出总情况 19 9 (47.36) 52.63 87 15 (17.24) 82.76 30 4 (13.33) 86.67 22 3 (13.64) 86.36 Summary 国家标准规定必须排除病原体 Pathogens required free of animals in national standards 肺炎克雷伯杆菌 19 0 (0) 100 87 2 (2.30) 97.70 30...
人乳腺癌中,CD39+PD-1+CD8+ ,但不是全部的CD8+ T细胞的频率与手术切除后的延迟转移性复发(无病生存)相关,因此强调了CD39+PD-1+CD8+T细胞在控制实验和人乳腺癌方面的生物学相关性。因此,本研究认为,原发性乳腺肿瘤可引发系统性CD39+PD-1+CD8+ T细胞反应,该反应有利于肺中转移性休眠。 引言 转移是乳腺癌...
纯化CD39 PD-1 CD8 T细胞的过继性转移防止了转移性生长。人乳腺癌中,CD39 PD-1 CD8 ,但不是全部的CD8 T细胞的频率与手术切除后的延迟转移性复发(无病生存)相关,因此强调了CD39 PD-1 CD8 T细胞在控制实验和人乳腺癌方面的生物学相关性。因此,本研究认为,原发性乳腺肿瘤可引发系统性CD39 PD-1 CD8 T细胞...