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[16]Ye, D., et al. First report of efficacy and safety from a phase II trial of tislelizumab, an anti-PD-1 antibody, for the treatment of PD-L1+ locally advanced or metastatic urothelial carcinoma (UC) in Asian patients. An...
作为临床治疗方案决策诊断级检测,经NMPA和/或FDA和/或CE IVD认证的PD-L1 IHC检测体系已有4种,均与特定药物和特定判读方法相关,不同PD-L1 IHC检测体系的临床治疗疗效预测价值在相应研究中亦得到相应临床验证[3,21-23]。4种获批PD-L1 IHC检测体系均高度标准化、...
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[16]Ye, D., et al. First report of efficacy and safety from a phase II trial of tislelizumab, an anti-PD-1 antibody, for the treatment of PD-L1+ locally advanced or metastatic urothelial carcinoma (UC) in Asian patients. Annals of Oncology 30 (2019): v367. ...
G. & Pardoll, D. M. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27, 450–461 (2015). Article CAS PubMed PubMed Central Google Scholar Blank, C., Gajewski, T. F. & Mackensen, A. Interaction of PD-L1 on tumor cells with PD-1 on tumor...
CJH1311,CESDLC5V0G3,CJ2301,CJP02N65,ESDBS1V8AH1,CJM05,ESDBL18VA1,CJM03,CJAC150N03A,ESDU5V0AE1,CJM06,CJM07,CJ4612SP,SBDF40100TCTB,CJ9112,CJ9113,CJAC13TH06,CJ9117,CJAB2003,CJ40563A420FC10,SBDF10100TCTB,ESDBL8V0D3,ESDH5V0P1,ESDH5V0FD1,ESDBU3V3A1,RS4MBF,JBF310,SMAJ36...
[6] Hirsch FR, McElhinny A, Stanforth D, et al. PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project. J Thorac Oncol. 2017;12(2):208-222. doi:10.1016/j.jtho.2016.11.2228 ...
Clinical Samples: Resultsof Blueprint Phase 2 Project. J Thorac Oncol. 2018; 13(9):1302-1311. [8] 郭雪晶, 曹赫, 周建娅,等. PD-L1检测方法在非小细胞肺癌的研究进展[J]. 中国肺癌杂 志, 2019, 22(1):5. [9] Doroshow, D. B., Bhalla, S., Beasley, M. B., Sholl, L. M., Kerr...
S1d). qRT-PCR assay validated the lower miR-140/142/340/383 expression or higher miR-18a expression in 60 primary CC tissues relative to matched adjacent normal tissues (Supplementary Fig. S2c). In CC samples, PD-L1 expression was positively correlated with miR-18a expression, but inversely ...