心电图:窦性心律、III度AVB、交界性逸搏,35bpm,未见QT/QTc延长(图1);心脏超声及胸片无异常;头颅CT:右侧半卵圆中心、放射冠区缺血梗死灶;NT-proBNP:3457 pg/ml;心肌酶谱:CK:577 U/l,CKMB:69.46 ng/ml,MYO:454.7 ng/ml;TnI和D-dimer:正常范围。肝...
Human PD-L1 Dimer Kit用于检测PD-L1的二聚化，可快速、高通量筛选使PD-L1产生二聚的化学小分子。试剂盒中有PD-L1-Eu(标记荧光供体Eu，PD-L1-Eu)，以及PD-L1-A2(标记荧光受体A2，PD-L1-A2)。当PD-L1发生二聚化时，PD-L1-Eu和PD-L1-A2距离靠近，可发生荧光共振能量转移(FRET)。使用320 nm的激发光激...
The unprecedented speed is enabled by the air-stable PdIdimer [Pd(渭-I)(PCy2tBu)]2, which in contrast to its PtBu3counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes....
Human PD-L1 Dimer Kit用于检测PD-L1的二聚化,可快速、高通量筛选使PD-L1产生二聚的化学小分子。试剂盒中有PD-L1-Eu(标记荧光供体Eu,PD-L1-Eu),以及PD-L1-A2(标记荧光受体A2,PD-L1-A2)。当PD-L1发生二聚化时,PD-L1-Eu和PD-L1-A2距离靠近,可发生荧光共振能量转移(FRET)。使用320 nm的激发光激发Eu...
We report the synthesis of air-stable Pd(I) dimer complexes featuring biaryl phosphine ligands. Catalytic experiments suggest that these complexes are comptent precatalysts that can mediate cross-coupling amination reactions between aryl halides with both aliphatic and aromatic amine nucleophiles. This wor...
Reduction of CO2 to free CO by a Pd(I)–Pd(I) dimer 来自 Semantic Scholar 喜欢 0 阅读量: 22 作者:CM Palit,DJ Graham,CH Chen,BM Foxman,OV Ozerov 摘要: Reaction of CO2 with a Pd(I)-Pd(I) dimer supported by amido/bis(phosphine) pincer PNP ligands produces free CO in the presence...
Targeting the PD-L1 dimer inhibits PD-L1 function PD-L1 can form homodimers and tetramers, and its complex glycosylation is linked to the homodimeric structure of its intracellular domain [190]. Natural compounds such as capsaicin, 6-gingerol, and curcumin may block the PD-1/PD-L1 interactio...
In the absence of pembrolizumab, the binding of the inactive PD-1 receptor to the PD-L1 dimer16 would trigger receptor dimerization, followed by the trans-phosphorylation of a tyrosine within the immunoreceptor tyrosine-based switch motif (ITSM), the recruitment of the protein tyrosine phosphatase ...
·In a mature tumor microenvironment (TME), VEGF dimer facilitate the interconnection or "daisy chaining" of multiple ivonescimab molecules. This enhances the synergistic effects of VEGF and PD-1 blockade. ·The presence of VEGF amplifies PD-1 binding strength by more than 18-fold. ·The prese...