Stop Solution:2 N H2SO4(Catalog #DY994) Microplates: R&D Systems (Catalog #DY990) Plate Sealers:ELISA Plate Sealers (Catalog #DY992) Scientific Data N/A View Larger Human PCSK9 / LDL R Complex ELISA Standard Curve Product Datasheets ...
Our data revealed that the M2 domain regulates the intracellular sorting of the PCSK9-LDLR complex to lysosomes, and that HFE is a new target of PCSK9 that inhibits its activity on the LDLR, whereas HLA-C enhances its function. This work suggests the potential modulation of...
siRNA (small interfering RNA) is a tool used to intervene in gene expression within an organism. Its mechanism of action involves precise pairing with the RNA sequence of the target gene, which then directs a protein complex known as RISC (RNA-induced silencing complex) to degrade these RNA ...
Human PCSK9/LDLR Complex DuoSet ELISA 中文名: 中文别名: CBNumber: CB015321536 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商1 Human PCSK9/LDLR Complex DuoSet ELISA化学性质 安全信息 Human PCSK9/LDLR Complex DuoSet ELISA性质、用途与生产工艺 ...
The mechanism by which the PCSK9-LDLR complex is sorted to degradation compartments is not fully understood. We previously suggested that out of the three M1, M2 and M3 subdomains of the C-terminal Cys/His-rich-domain (CHRD) of PCSK9, only M2 is critical for the activity of extracellular...
(RosettaDock), for docking unbound components of PCSK9 and LDLR (BSA ~500A) Wefound that this resulted in the generation of unstable models, which were all found to begrossly different from the native structure of the PCSK9-LDLR complex (PDB ID: 3M0C)by the CAPRI Assessment Criteria, ...
To find new binding partners for PCSK9, we used a shotgun proteomic method to analyse the protein complex pulled down by immunoprecipitation against FLAG-tagged PCSK9 protein. Among 22 potential novel binding proteins identified, we found that the cellular inhibitor of apoptosis protein 1 (c-IAP...
The presence of SEC24A in the COPII complex is necessary for the efficiency of this exit [29]. Our analysis indicated that SEC24A expression is not affected by Q3G. In the TGN, PCSK9 packaging into secretory vesicles is facilitated by the protein sorting receptor sortilin [30]. Here we ...
Hypercholesterolemia is a complex trait, resulting from a genetic interaction with lifestyle habits. Polymorphisms are a major source of genetic heterogene... T Zambrano,MH Hirata,Álvaro Cerda,... - 《International Journal of Clinical & Experimental Medicine》 ...
Recent evidence shows that in addition to the straightforward mechanism of action, there are more complex interactions between PCSK9, LDLR and plasma lipoprotein levels, including: (a) the presence of both parallel and reciprocal regulation of surface LDLR and plasma PCSK9; (b) a correlation ...