Although the mechanism of action of ibogaine, a hallucinogen that may be useful in the treatment of addiction, remains unknown, receptor binding studies suggest that ibogaine produces its effects via interactions with multiple receptor types. In addition to serotonergic receptors, which have been ...
To elucidate the mechanism of hepatocarcinogenesis of pentachlorophenol (PCP) in mice, critical effects related to carcinogenicity were studied in the livers of B6C3F1 male mice administered PCP at concentrations of 600 and 1200 p.p.m. in the diet for 8 weeks. Oxidative stress was assessed by ...
In studying the mechanism of action of 6-azauridine-5′-diphosphate it was found that it markedly inhibits the incorporation of amino acids into soluble RNA, the inhibition being counteracted by CTP. 6-Azauridine-5′-diphosphate also inhibits the incorporation of [ 32P]CMP into soluble RNA as...
These results suggest that the function of the NMDA-PCP receptor complex is impaired by increases in membrane fluidity. These findings may be pharmacologically relevant in understanding the mechanism of action of such agents as general anesthetics and ethanol, which cause increases in plasma membrane ...
J Paul Simons2 and Simon Lovestone1 Although the mechanism of Ab action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of Dkk1 blocks Ab neu...
A new mechanism for pyrrole synthesis has been suggested from precursor labeling studies on the biosynthesis of pyoluteorin [5], coumermycin A1 [11], undecylprodigiosin [12], and prodigiosin [13]. These labeling studies found that L-proline was the precursor for the pyrrole moieties in pyo...
The present study aimed to explore the ability of two anticonvulsants with differing mechanism of action, valproate and phenytoin to attenuate the cognitive deficits induced by PCP and d-amphetamine in the reversal learning paradigm. PCP at 1.5mg/kg and d-amphetamine at 0.5mg/kg both produced a...
Although the mechanism of Aβ action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of Dkk1 blocks Aβ neurotoxicity. We asked if clusterin, ...
All of these binding sites are conserved in zebrafish Lpp, providing a possible mechanism through which downregulation of lpp expression could account for the observed C&E defects. The results described in this paper indicate that expression of lpp in zebrafish is dependent on noncanonical Wnt/PCP ...
The Ft activity information is relayed into the cells (by an unknown mechanism) through the action of the plasma membrane receptor Frizzled (Fz)5, and as a result a Fz activity disparity results in the R3/4 pair. This Fz activity differential is then relayed to a Notch/Delta (N/Dl) ...