HOXA10可调控胰岛素样生长因子结合蛋白-1(insulin-like growth factor binding protein-1, IGFBP-1)基因与子宫内膜整合素αυβ3基因的表达,还可以与转录因子MEIS1结合形成二聚体共同参与子宫内膜容受性的建立[29]。HOXA11可抑制催乳素基因的表达。最新研究...
肥胖型PCOS患者70%~80%伴有胰岛素抵抗(insulin resistance,IR),而IR可通过干预葡萄糖摄取及代谢,导致HOXA10 基因表达异常,致使免疫抑制性糖蛋白和人胰岛素样生长因子结合蛋白-1(insulin-like growth factor-binding protein-1, IGFBP-1)血...
Distress response in granulosa cells of women affected by PCOS with or without insulin resistancePCOSHyperinsulinemiaUnfolded protein responseEndoplasmic reticulumMitochondriaMetabolic distressEndocrine - In this study, we investigated whether metabolic dysfunction in women with Polycystic ovarian syndrome (PCOS) ...
PCOS患者治疗前后性激素的变化及其与胰岛素抵抗、肥胖的关系 ［４］ 陈乙菲，隋殿军．血府逐瘀汤在不同系统疾病中的作用机制研究 进展［Ｊ］．吉林中医药，２０２０，４０（５）：６９３－６９６．［５］ 中华医学会妇产科学分会子宫内膜异位症协作组．子宫内膜异位 症的诊治指南［Ｊ］．中华妇产科杂志，２０１５，...
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not. Women can have insulin resistance without PCOS, but still have lactation trouble. Women can have PCOS and insulin resistance and have no lactation trouble. While less common and much less understood, women can have lactation trouble (in the form of IGT) without PCOS or insulin resistance....
withoutinsulinresistance. 2.Therealeno significant differencesofthe T'FSH,LH andPRLbetween thePCOS patient withorwithout obesity.The serum glucose and plasma insulin levelof patients with obesity inOGTTare significanthigher thanthat of patients
Insulin-resistant PCOS.Often, those who have PCOS also haveinsulin resistance, which is when your body makes the hormone insulin but can't use it correctly. Insulin resistance increases your risk for type 2 diabetes. Inflammatory PCOS.Inflammation results when your immune system tries to fight off...
Insulin-resistant PCOS.This type refers to PCOS that involves insulin resistance as a main component. With insulin resistance, the body’s cells don’t react to Symptoms and Signs PCOS symptoms can begin around puberty, after the first menstrual cycle, though some may not ...
Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis J. Clin. Endocrinol. Metab., 97 (10) (2012 Oct), pp. E2016-E2021 ...