Cancer of ProstateDiagnosticIn UrineResearchers from the University of California Los Angeles (CA, USA) suggest that a urine test for the prostate cancer gene 3 (PCA3) may improve screening for prostate cancer.Usually, prostate cancer screening involves the measurement of a protein called prostate ...
WilliamJ.Ellis, HarryRittenhouse,andJackGroskopf OBJECTIVES Menwithelevatedserumprostate-specificantigen(PSA)levelsandnegativeprostatebiopsy findingspresentadilemmabecauseofthelackofanaccuratediagnostictest.Weevaluatedthe potentialutilityoftheinvestigationalprostatecancergene3(PCA3)urineassaytopredictthe repeatbiopsyoutcome...
PCA3 refers to a noncoding messenger RNA that is found to be significantly elevated in more than 90% of men with prostate cancer (PCa), but not in normal prostatic glands or benign prostatic hypertrophy. It is a urine-based diagnostic test approved by the FDA to determine the need for re...
PCA3 is a non-coding mRNA molecule that is overexpressed in prostate cancer. The purpose of this study is to evaluate the utility of the PCA3 molecular urine test scores to predict adverse pathologic features and catheterized specimen collection. Hundred men with clinically localized prostate cancer...
(f/tPSA) in men with a previous negative biopsy and a PSA level of 2.5–10 ng/mL, as urine tests like PCA3 are currently under investigation in order to improve prostate cancer diagnosis and to decrease the rate of unnecessary rebiopsies.PATIENTS AND METHODSData from the previous prospective...
Therefore, this DD3 PCA3-based RT-PCR assay was used for the identification of prostate cancer in urine sediments obtained after prostatic massage. From 108 men with a serum PSA value >3 ng/ml, 24 men were shown to have prostate cancer upon biopsy. Of these 24 men, 16 were shown to ...
Moreover, the PCA3 test showed a prognostic value, as higher PCA3 score values are associated to a greater tumor aggressiveness. 展开 关键词: Prostate Specific Antigen Urine and blood biomarkers Prostate Cancer gene 3 Tumor aggressiveness Prostate cancer Oncology DOI: 10.1186/s13046-015-0127-8 ...
Clinical validity There are three scenarios investigated in the evidence review.25 The first two relate to the use of the urine PCA3 test and other biomarker tests to predict detection of prostate tumor at biopsy or rebiopsy of at-risk men based primarily on elevated tPSA and/or suspicious ...
PCA3 Molecular Urine Assay Correlates With Prostate Cancer Tumor Volume: Implication in Selecting Candidates for Active Surveillancedoi:10.1016/S0084-4071(08)79032-8AndrioleG.L.ELSEVIERYearbook of UrologyNakanishi H, Groskopf J, Fritsche HA, et al. PCA3 molecular urine assay correlates with prostate...
Real-time PCR PCA3 assay is a useful test measured in urine to improve prostate cancer detection 来自 国家科技图书文献中心 喜欢 0 阅读量: 8 作者:Lourdes,Mengual,Antonio,Alcaraz,Montserrat,Mila,Pilar,Luque,Laura,Foj 摘要: Background: The usefulness of PCA3 in the manageme ...