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Historically, the care process for these patients has been to do a biopsy. Then, if it is positive and the patient has metastases, androgen deprivation therapy (ADT) is started, and the patient is followed. Over the past few years, there have been multiple clinical trials that have led to...
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(OHu18395D), all in pcDNA3.1-C-(k)DYK plasmid backbone, as well as control pcDNA3.1-C-(k)DYK plasmid, were obtained from GenScript (Piscataway, NJ, USA). Nude (Nu/J) mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA). All other reagents were obtained from commercial...