生化机理PC786 是一种吸入性呼吸道合胞病毒(RSV)L 蛋白聚合酶抑制剂。PC786 对 RSV-A (IC 50 <0.09 至 0.71 nM)和 RSV-B (IC 50 , 1.3 至 50.6 nM)具有强效抗病毒活性。 储存温度避光,-20°C储存,充氩 运输条件超低温冰袋运输 作用类型抑制剂 ...
RSV replicates in the columnar epithelial cells of the proximal and distal airways which are accessible to inhaled therapies. PC786 is a potent non-nucleoside RSV L-protein polymerase inhibitor designed for inhaled delivery. In preclinical studies, PC786 exhibits prolonged lung tissue residence with ...
PC786 inhibits RSV B WST activity, exhibiting an IC50 and IC90 of 27.3±0.77 nM and 57.1±3.87 nM, respectively [1]. 体内活性 Treatment with PC786 (either intratracheal or intranasal; Once-daily on days-1 to 3), is found to inhibit viral loads in the lungs of RSV A2-infected BALB/...