Acta Pharmacologica Sinica 2006 Aug; 27 (8): 981–990 Full-length article TRPC3 is involved in flow- and bradykinin-induced vasodilation in rat small mesenteric arteries1 Cui-ling LIU2,4, Yu HUANG3, Ching-yuen NGAI3, Yuk-ki LEUNG3, Xiao-qiang YAO3 2Department of Pathology, Peking ...
In the present study, a human induced pluripotent stem cell (iPSC) line ZZUNEUi025-A was generated from peripheral blood mononuclear cells of a male HCM patient with c. 772+1G > A in MYBPC3 gene. This cell line expressed pluripotency markers, had normal male karyotype and could ...
Mean number of RIF per cell nuclei as a function of simulated mean number of hits per cell nuclei for the elliptical cylinder phantom (a) and the mesh volume phantom (b), respectively. Error bar 1 +—SD. Linear regression by linear least squares method seen as dotted line Full size im...
Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line. Cell Calcium 2006;39:401-15 Preston SF, Sha'afi RI, Berlin RD. Regulation of Ca2+ influx during mitosis: Ca2+ influx and depletion of intracellular Ca2+ stores are coupled ...
of α-tomatine against the prostate cancer cells was 200 times greater than that of the aglycone tomatidine, and (d) the activity increased as the number of sugars on the aglycone increased, but this was only statistically significant at p < 0.05 for the normal lung Hel299 cell line. The...
Full-length repaired Mybpc3 mRNA represented up to 66% of total Mybpc3 transcripts in cardiac myocytes and 0.14% in the heart. Repaired cMyBP-C protein was detected by immunoprecipitation in cells and in vivo and exhibited correct incorporation into the sarcomere in cardiac myocytes. This study ...
Full size image Setting up the SCFS assay to characterize the crosstalk of ephrins to cell adhesion receptors Ephrin-A1 binding stimulates PC3 cells to strengthen adhesion to collagen I Full size image Only ephrin-A1 bound to a surface stimulates PC3 cells to strengthen adhesion to collagen I ...
It was recently shown that truncation of 29 residues of the C-terminus of GIPC1 abolishes interaction with Myosin VI suggesting that the full-length C-ter- minus is required to form stable interactions33. In addition, both Leu262 and Trp301 residues are highly conserved among metazoan GIPC ...
form of genome editing that enables direct conversion of individual nucleotides at specific genomic sites, without introducing a double-strand DNA break.4,5Over the last few years, base editing has emerged as a powerful technology to change or generate genetic variants in a wide range of mitotic...
(Nox2). Although TRPC3 has been long suggested to form hetero-multimer channels with TRPC6 and function as diacylglycerol-activated cation channels coordinately, the role of TRPC6 in heart is still obscure. We here demonstrated that deletion of TRPC6 had no impact on pressure overload-induced...