GPR40, GPR84[1] 体内研究PBI-4050是中链长度脂肪酸的合成类似物,与FFA受体1(FFAR1/GPR40)和GPR84结合。为了确定PBI-4050对糖尿病肾病的潜在作用,使用了2型糖尿病肾病的加速模型eNOS -/- db/db小鼠。用8-20周龄的每日管饲法用载体或PBI-4050(100mg/kg)处理小鼠。 eNOS -/- db/db小鼠是中度高血压,PB...
setogepram is an orally active gpr40 agonist and is an antagonist or inverse agonist of gpr84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. 价格:￥电议型 号:T12883产 地:中国大陆 T12375Setogepram sodium saltSetogepram sodium salt,PBI-4050 sodium salt, ...
orally active compound that has completed clinical Phases Ib and II in subjects with chronic kidney disease (CKD) and metabolic syndrome respectively, exerts antifibrotic effects in several organs via a novel mechanism of action, partly through activation of the G protein receptor 40 (GPR40) ...
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PBI-4050, a GPR40 agonist/GPR84 antagonist, displays anti-fibrotic, anti-inflammatory and anti-proliferative activities.Hypothesis: We evaluated PBI-4050 for the treatment of PH in a HFrEF model and investigated its effect on the expression of profibrotic markers in TGF-β-stimulated human lung ...
PBI-4050, a dual GPR40 agonist/GPR84 antagonist with anti-fibrotic and anti-proliferative activities, is a lead drug candidate in pivotal phase 2/3 clinical trial for IPF.Hypothesis: We evaluated the therapeutic efficacy of PBI-4050 for the treatment of PAH in the hypoxia-Sugen (HS) model,...
PBI-4050 is a dual GPR40 agonist/GPR84 antagonist with antifibrotic and antiproliferative activities.Hypothesis: The aim was to evaluate PBI-4050 in comparison with sildenafil in the angio-proliferative model of Hypoxia/Sugen (HS) PAH. Additionally, mechanistic effects of PBI-4050 were assessed in...
PBI-4050 is a first-in-class dual GPR40 (agonist)/GPR84 (antagonist) receptors modulator. Administered late (2 weeks) after myocardial infarction (MI), PBI-4050 reduces PH, RVH and lung fibrosis.Hypothesis: PBI-4050 administered early after large MI does not adversely affect scar healing and...