8. Calabretta E, Hamadani M, Zinzani PL, Caimi P, Carlo-Stella C. THE ANTIBODY-DRUG CONJUGATE LONCASTUXIMAB TESIRINE FOR THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA. Blood 2022; 9. Hartley JA. Antibody-drug co...
当Loncastuximab tesirine与表达CD19的肿瘤细胞结合时，会被细胞内化，随后释放吡咯并苯二氮杂䓬二聚体（PBD Dimer）细胞毒素。该毒素能不可逆地与DNA小沟相结合，并且形成高强度的链间交联，从而破坏复制等必要的DNA代谢过程，进而诱导细胞死亡。这一独特的作用机制，使得PBD dimer引起了大众的关注。▲ Fig.1 Lo...
Loncastuximab tesirine是国内首款靶向CD19的抗体偶联药物(ADC)。 当Loncastuximab tesirine与表达CD19的肿瘤细胞结合时,会被细胞内化,随后释放吡咯并苯二氮杂䓬二聚体(PBD Dimer)细胞毒素。该毒素能不可逆地与DNA小沟相结合,并且形成高强度的链间交联,从而破坏复制等必要的DNA代谢过程,进而诱导细胞死亡。这一独...
Release date April 5, 2022 (United Kingdom) Production company PBD Podcast See more company credits at IMDbPro Edit Runtime 1hour47minutes Suggest an edit or add missing content IMDb Answers: Help fill gaps in our data Learn more about contributing ...
▲ Fig.1 Loncastuximab tesirine 中连接子和有效载荷PBD的结构[1] PBD简介 吡咯并苯二氮杂䓬(PBD)是一种序列选择性的DNA小沟结合剂,是抗生素炭疽霉素家族中的一员。[1]此外,科学家们还发现,通过亚甲基链将两个PBD单元连接在一起,可以使PBD二聚体与DNA之间产生高度致命的链间交联。而且这种PBD二聚体在...
हिंदी (भारत) Italiano (Italia) Português (Brasil) Español (España) Español (México) Peter Navarro On China's Threat To The U.S. | PBD Podcast | Ep. 265 | Part 1(2023 Podcast Episode) See agents for this cast & crew on IMDbPro...
▲ Fig.1 Loncastuximab tesirine 中连接子和有效载荷PBD的结构[1] PBD简介 吡咯并苯二氮杂䓬(PBD)是一种序列选择性的DNA小沟结合剂,是抗生素炭疽霉素家族中的一员。[1]此外,科学家们还发现,通过亚甲基链将两个PBD单元连接在一起,可以使PBD二聚体与DNA之间产生高度致命的链间交联。而且这种PBD二聚体在...
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2020年1月10日,ADC Therapeutics公布了loncastuximab tesirine 在(ADCT-402)治疗复发性或难治性弥漫性大B细胞淋巴瘤(r/r DLBCL)患者中Ⅱ期临床试验的积极结果,据该公司称,此次公布的临床数据结果已经超过其主要终点,loncastuximab te...
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