1.Hiremath S,McGuinty M,Argyropoulos C,Prescribing Nirmatrelvir/Ritonavir for COVID-19 in Advanced CKD.CJASN.2022,17: 1247–1250. 2.Nirmatrelvir/ritonavir use: Managing clinically significant drug-drug interactions with transplant immunosuppressants.Am J Transplant. 2022,00:1-2. 作者介绍 崔向...
4. Cully M. A tale of two antiviral targets - and the COVID-19 drugs that bind them. Nat Rev Drug Discov. 2022;21(1):3-5. 5. 国家药监局应急附条件批准辉瑞公司新冠病毒治疗药物奈玛特韦片/利托那韦片组合包装进口注册。国家药品...
2021年12月22日,美国食品药品监督管理局(FDA)授予了口服抗新冠病毒药物奈玛特韦/利托那韦(Paxlovid)的紧急使用授权,用于治疗有进展为重症肺炎高风险因素的轻至中度新型冠状病毒肺炎的成人患者和12岁及以上、体重至少40kg的儿童患者。这些患者在直接SARS-CoV-2病毒测试中被检测为阳性,并且有进展为重度新冠肺炎(包括住院...
[11] U.S. Food and Drug Administration. Coronavirus (COVID-19) Update: FDA Authorizes First Oral Antiviral for Treatment of COVID-19.[2021-12-22] https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19 [12]Half...
为了全面探索小分子抗病毒药物预防和治疗COVID-19感染方面的价值,Paxlovid开展了4项注册III期研究,分别针对重症高风险人群(EPIC-H5R研究)、重症低风险人群(EPIC-SR研究)、密切接触人群(EPIC-PEP研究)和18岁以下重症高风险人群(EPIC-Peds研究),目前...
[2] Gil C, Ginex T, Maestro I, et al. COVID-19: Drug Targets and Potential Treatments. J Med Chem. 2020;63(21):12359-12386. doi:10.1021/acs.jmedchem.0c00606 [3] Zhang L, Lin D, Kusov Y, et al. α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus ...
在COVID-19 确诊以及出现症状后 5 天内尽快服用。如果患者在开始服用该药品治疗后,因重症或危重 COVID-19 需要住院,也建议完成 5 天的治疗。 服用剂量: 推荐剂量为奈玛特韦 300 mg(150 mg×2 片)联用利托那韦 100 mg(100 mg×片),每12小时一次口服给药,连续服用 5 天。
4. Cully M. A tale of two antiviral targets - and the COVID-19 drugs that bind them. Nat Rev Drug Discov. 2022;21(1):3-5. 5. 国家药监局应急附条件批准辉瑞公司新冠病毒治疗药物奈玛特韦片/利托那韦片组合包装进口注册。国家药品监督管理局,XZXK-2022-120。
通常暗示是经过付出了很多努力才找出的(to look for and find sb/sth, especially when this means using a lot of effort )。 长句分析 People // withcovid// in these areas // may be less likely to seek out and obtain the drug // when it is effective, // during the first five days of...
Surge | NEJM 3.NIH官网https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/ritonavir-boosted-nirmatrelvir--paxlovid-/paxlovid-drug-drug-interactions/ 4.《新型冠状病毒感染者抗病毒治疗专家共识》https://mp.weixin.qq.com/s/NsiPE09dhUpOe6t5-vh9SA ...