Pain is the single most frequent reason for seeking medical care. Several theories have developed to explain the pathogenesis and conductance of pain, including the Specificity Theory, Pattern Theory, Gate Control Theory, and Biopsychosical Model. As the theories have matured, we are better able ...
Thus, two fundamentally different forms of spinal analgesia can be evoked by transcutaneous electrical nerve stimulation (TENS) and (electro-) acupuncture: The analgesia during TENS at low Aa/b-®ber intensity causing paresthesia but no pain is best explained by the gate-control theory (Melzack...
et al. Gate control of mechanical itch by a subpopulation of spinal cord interneurons. Science 350, 550–554 (2015). Article ADS CAS Google Scholar Melzack, R. & Wall, P. D. Pain mechanisms: a new theory. Science 150, 971–979 (1965). Article ADS CAS Google Scholar Duan, B., ...
IMPACT—the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia Michael Berk Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia ...
3.3Differential expression patterns analysis of hHubGs To investigate the differential expression patterns of hHubGs (CDK2, CHEK1, MKI67, TOP2A, CDK1, BRCA1, PLK1, CCNA2, CCNB1, TYMS) between CC and control samples, we performed box-plot analysis by using the GEPIA web-tool (see Fig....
Neurotrophins are most often associated with the promotion of neuronal growth and survival, but their influence on brain function is significantly broader — they are also involved in plastic and pathological processes. Clues to the multiple functions of neurotrophins come from the study of mutant ani...
It may not be quite clear when the study of pain pathways began, but it is almost certain that it gained focus with the reflex theory advanced by Descartes (1664) and was rejuvenated time and again by a number of subsequent theories, such as the specificity theory (Schiff 1858), the ...
[19,22]. Activated WDR neurons have been long suspected to be the gatekeepers according to the gate control theory of pain [23,24]. A current opinion piece postulated that the loss of these signaling pathways, leading to miswired proprioception, could be one reason why the primary pain is ...