Parkinson's disease (PD) is a complex disorder with many different causes, yet they may intersect in common pathways, raising the possibility that neuroprotective agents may have broad applicability in the treatment of PD. Current evidence suggests that mitochondrial complex I inhibition may be the ...
CooksonGladstoneLeonardGladstonePetrucelliGladstoneAlbertGladstoneRGladstoneLaGladstonePubmedNature NeuroscienceGan, L.; Cookson, M.R.; Petrucelli, L.; La Spada, A.R. Converging pathways in neurodegeneration, from genetics to mechanisms. Nat. Neurosci. 2018, 21, 1300-1309. [CrossRef]...
The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed. One problem that investigators face is distinguishing primary from secondary events. Rare, inherited mutations causing familial forms of these disorders have provided important insights into the molecular...
Through a detailed review of ubiquitin proteasome, mRNA splicing, mitochondrial dysfunction, and oxidative stress pathway interrelation on neurodegeneration can improve the understanding of the disease mechanism. The identified pathways common to AD and PD nominate promising new targets for further studies,...
Molecular pathways to neurodegeneration The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed. One problem that investigators face is disting... E Bossy-Wetzel,R Schwarzenbacher,SA Lipton - 《Nature Medicine》 被引量: 1493发表: 2004年 Intersecting pat...
Inflammatory priming of the substantia nigra influences the impact of later paraquat exposure: Neuroimmune sensitization of neurodegeneration. Neurobiol Aging 2008; 30(9):1361–1378 Google Scholar Teismann P, Vila M, Choi DK, et al. COX-2 and neurodegeneration in Parkinson’s disease. Ann N Y...
Neurodegeneration and inflammation pathways are associated to early amyloid deposition. The fact that biomarkers of these pathways show interactive effects with the main AD risk factors (age, sex and APOE│ also suggests that they play different roles in the early stage of the Alzheimer's continuum...
et al. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci. Transl Med. 8, 347ra93 (2016). Article PubMed PubMed Central CAS Google Scholar Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. ...
In this review, we discuss the importance of cellular NAD+ in aging, neurodegeneration, metabolic disorders, and cancer. 2. NAD+ biosynthesis pathways The intracellular concentration of NAD+ is a balance between NAD+ consumption and synthesis. The biosynthetic pathways of NAD+ play an important ...
Wang LH, Besirli CG, Johnson EM: Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu Rev Pharmacol Toxicol 2004, 44: 451-474. 10.1146/annurev.pharmtox.44.101802.121840 Google Scholar Weggen S, Rogers M, Eriksen J: NSAIDs: small molecules for prevention of Alzheimer...