Fungi have evolved at least three distinct endocytosis-mediated heme uptake systems, which have been studied in detail in the organisms Candida albicans, Cryptococcus neoformans and Schizosaccharomyces pombe. Here we summarize the known molecular details of these three uptake systems that enable parasitic...
The gastrointestinal system contains countless microorganisms spanning multiple kingdoms performing diverse functions. Archaea, bacteria, viruses, and fungi work in concert and competition to acquire nutrients and space [1]. The focus of previous gut microbiome research has predominantly been on the identif...
Fungal virulence is regulated by a tight interplay of transcriptional control and chromatin remodelling. Despite compelling evidence that lysine acetylation modulates virulence of pathogenic fungi such asCandida albicans, the underlying mechanisms have remained largely unexplored. We report here that Gcn5, a...
Finally, natural phenolic compounds, a group of secondary metabolites also derived from fungi, possess strong antioxidant capabilities in terms of lipid peroxidation inhibition and DPPH scavenging activity (Palacios et al., 2011; Lu et al., 2013; Wang et al., 2013). Furthermore, there are ...
Fungal virulence is regulated by a tight interplay of transcriptional control and chromatin remodelling. Despite compelling evidence that lysine acetylation modulates virulence of pathogenic fungi such as Candida albicans, the underlying mechanisms have
FungiCFEM proteinHemophoreIron acquisition is challenging in most environments. As an alternative to elemental iron, organisms can take up iron-protoporphyrin IX, or heme. Heme can be found in decaying organic matter and is particularly prevalent in animal hosts. Fungi have evolved at least three ...
Most prominently, cysteine oxidation to taurine accounts for around 50% of cysteine pool utilization in most tissues [112]. Taurine serves various cellular functions including osmotic pressure regulation, cellular membrane stabilization, calcium signaling regulation, mitochondrial biogenesis upregulation, neuro...
utilization, and the combinatory proteomics and bioinformatics strategies used in this study can also be applied into other systems to reveal the metabolic and regulatory pathways for balanced cellular metabolism and to select genetic targets for efficient conversion of both lignin and carbohydrates into ...
Nutrient sensing pathways and their regulation grant cells control over their metabolism and growth in response to changing nutrients. Factors that regulate nutrient sensing can also modulate longevity. Reduced activity of nutrient sensing pathways such as glucose-sensing PKA, nitrogen-sensing TOR and S6...
This study was undertaken in order to find the anti-aging role of the fungi, which can provide a theoretical basis for the development and utilization of Agaricus blazei. 2. Research design and methods 2.1. Material and reagents The fruiting bodies of Agaricus blazei (Jiangsu Suwei Microbial ...