of the GLI target gene BCL2.19,20 1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 2Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY, USA; 3Department of Dermatology, The University of Colorado-Anschutz Medical...
Association of hallmarks to aging, such as the genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication, suggests the involvement of multiple ...
a, Manhattan plot showing the distribution of IBS-associated SNPs across the genome. The dashed line indicates the genome-wide significance threshold atP = 5 × 10−8.Pvalues are from a two-sided test, after inverse variance-weighted fixed-effects meta-analysis. See Supplementary Fig....
The oncogenic transformation of a cell requires several mutations conferring abnormal properties that may include independence from the requirement for growth stimulatory signals, loss of sensitivity to growth inhibitory signals, the acquisition of unlimited proliferative capacity, suppression of apoptotic signal...
Institute of Molecular and Cellular Biology, University of Tartu, Tartu, Estonia V Jaks Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA E R Flores Department of Molecular Biology, University of Salzburg, Salzburg, Austria W Grube...
Department of Leadership in Education, University of Massachusetts Boston, Boston, MA 02125, USA 2 Department of Urban Education, University of Houston-Downtown, Houston, TX 77002, USA 3 The Learning Partnership, Chicago, IL 60603, USA * Author to whom correspondence should be addressed. Educ....