Through this exploration of Himalayan flora, this review seeks to illuminate potential breakthroughs in lung cancer management using natural compounds. The amalgamation of Himalayan plant-derived compounds with cautiously designed combined therapeutic approaches such as nanocarrier-mediated drug delivery and syn...
Adoptive transfer of genetically engineered chimeric antigen receptor (CAR) T cells is becoming a promising treatment option for hematological malignancies. However, T cell immunotherapies have mostly failed in individuals with solid tumors. Here, with a
Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Res Bull 2001; 54(4):443–453 Article PubMed CAS Google Scholar Maier SF, Nguyen KT, Deak T, et al. Stress, learned helplessness...
Approximately 35% of all food and drug administration (FDA)-approved drugs target GPCRs5,6, stressing their importance for biomedical research and drug development. However, major challenges exist in investigating GPCR signaling. First, several GPCRs have unidentified ligand and are therefore ...
This study was conducted in accordance with the Helsinki Declaration II, and was approved by the Institutional Review Boards of Harbin Medical University (HMUIRB 2012001) and the Administration Village Committee. Written informed consent was obtained from the parents or guardians of all children. Avai...
Background: Administration of antimicrobials to food animals, including non-therapeutically, can select for antimicrobial-resistant (AMR) bacterial pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), and influence microbial communities due to selective pressure. In the United States, ...
Next, we used a different treatment-naive RA patient (donor 3) to colonize germ-free mice prior to the oral or intraperitoneal (IP) administration of MTX (route) and prior to oral MTX with or without an equimolar level of folic acid (rescue). Neither route nor rescue resulted in a ...
Methodologically, to answer the second sub-research question (What factors affect the utilisation of mortgages?), a logistical regression was employed that models the probability of an event taking place by having the log odds for the event be a linear combination of one or more independent variab...
In a tail vein injection pulmonary metastasis mouse model, intraperitoneal administration of garcinol (20 mg/kg) or 5-FU (20 mg/kg) significantly decreased the number of lung tumor nodules and the expression levels of Ki-67, p300, and p-Smad2/3 in lung tissues. In conclusion, our ...
Editorial Commission of Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine (Ed.) (1999) Traditional Chinese Medicine, vol 7. Shanghai Science & Technology Press, Shanghai Fan YY, Sun YL, Zhou B, Zhao JX, Sheng L, Li JY, Yue JM (2018) Hedyorienoids A and B...