The Hippo pathway effectors YAP (also known as YAP1) and TAZ (also known as WWTR1) are regulated by mechanical cues and mediate cellular responses to ECM stiffness. Here we identified the Ras-related GTPase RAP2 as a key intracellular signal transducer that relays ECM rigidity signals to ...
Activating transcription factor-2 (ATF2) was found to be a target of the JNK signal transduction pathway. ATF2 was phosphorylated by JNK on two closely spaced threonine residues within the NH_2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the ...
fragilis signals through TLR2 directly on Foxp3+ regulatory T cells to promote immunologic tolerance. B. fragilis lacking PSA is unable to restrain T helper 17 cell responses and is defective in niche-specific mucosal colonization. Therefore, commensal bacteria exploit the TLR pathway to actively ...
Rosen, Essential Requirement for Sphingosine Kinase 2 in a Sphingolipid Apoptosis Pathway Activated by FTY720 Analogues, J. Biol. Chem., 282 (2007) 15833-15842.Don, A. S., C. Martinez-Lamenca, W. R. Webb, R. L. Proia, E. Roberts, and H. Rosen. 2007. Essential requirement for ...
Frucht, "Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells," Carcinogenesis, vol. 22, no. 9, pp. 1379- 1383, 2001.Yang WL, Frucht H. Activation of the PPAR pathway induces apoptosis and COX- 2 inhibition in HT-29 human colon ...
Variation in use of the 2-week referral pathway for suspected cancer: a cross-sectional analysis. Br J Gen Pract 2012; 62(602): 590-597. doi: 10.3399/bjgp12X654551Meechan D, Gildea C, Hollingworth L, et al. Variation in use of the 2-week referral pathway for ...
Atmospheric transport is a major pathway of microplastics to remote regionsAtmospheric scienceEnvironmental impactEnvironmental impactIn recent years, marine, freshwater and terrestrial pollution with microplastics has been discussed extensively, whereas atmospheric microplastic transport has been largely overlooked....
ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen receptor-dependent HIF2alpha/VEGF signaling pathway. Cancer Res. 2014; 74:4420-4430.He D, Li L, Zhu G, Liang L, Guan Z, Chang L, et al. ASC-J9 suppresses renal cell carcinoma progression by targeting an androgen...
Thus, HGF triggers activation of the COX-2 gene in gastric epithelial cells through phosphorylation of c-Met/HGF receptor and activation of the ERK2 signaling pathway.-Jones, M. K., Sasaki, E., Halter, F., Pai, R., Nakamura, T., Arakawa, T., Kuroki, T., Tarnawski, A. S. HGF...