Worldwide variations were observed in the circumstances, cultures, outbreaks, and strategies employed to manage COVID-19. Overprotection of medical students is not required; their involvement in a properly optimized pandemic system is both appropriate and profitable for their professional paths. A ...
Cancer remains a major cause of mortality worldwide, especially in China1,2,3, and GC ranks as the fifth most common cancer and ranks fourth among causes of cancer-related death globally4. Although the past decade has witnessed significant inroads in surgery, chemotherapy, radiotherapy, and biol...
Alcoholic liver disease (ALD) is the main cause of cirrhosis worldwide1 and the main driver of health expenditure in hospitalized patients with liver disease in the US2. In clear contrast with the recent advances in viral hepatitis, there are no targeted therapies for patients with ALD. In ...
A. Histogram showing cross-cancer summary of copy number alterations for SOX2, SHH, PTCH, SMO and GLI1 (28 studies/5 genes) depicted wide-spread alterations in all the 5 genes in almost all cancer types. B. Oncoprint analysis in prostate cancer showed that SOX2 was amplified in 8%, SHH...
HCC is the most common primary liver cancer, accounting for approximately 90% of all liver cancer cases[1]. According to the World Health Organization, HCC is currently the fifth most common cancer worldwide and the third leading cause of cancer-related mortality[2]. HCC is a common malignant...
Mao1,2 · Shufen Zhang2 · Ying Cai2 · Wei Chen1,2 Received: 2 February 2023 / Accepted: 14 June 2023 / Published online: 22 June 2023 © The Author(s) 2023 Abstract Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide....
Through a genome-wide CRISPR screen, Michael A et al. [23] found that ENL is necessary for the growth and proliferation of MLL-AF4-positive acute myeloid leukemia(AML) cell lines. However, our use of CRISPR/Cas9 to screen for liver metastasis in CRC is the first report in the world, ...
It is estimated that there are 2.3 million new breast cancer cases worldwide, accounting for 11.7% of the world’s new cases. As the malignant tumor with the largest number of cases in the world, breast cancer surpassed lung cancer for the first time, with 18.4% of the global new cases...
In graphs (B, E, G–J, and K–M), statistical p values by two-way Student’s t test are indicated as ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. See also Figure S5. Inhibition of the Cholesterol Pathway Regulates Autocrine TGF-β Signaling via SREBP1 To investigate ho...
All comparisons between the two sets of quantitative data were performed using paired or unpaired two-tailed, two-sided Studentt-tests, as the variances were similar between the groups under comparison. All comparisons among multiple sets of quantitative data were analyzed using one-way analysis of...