Back on a beautiful autumn day in Seattle, which also just happened to be my 50th birthday, I was selected as the 2012 Ruth McCorkle Award Lecturer by the Puget Sound Oncology Nursing Society (ONS) chapter. The lectureship was started in 1987 as a special tribute to Ruth McCorkle, PhD,...
A logistic additive model with a test negative case control design was used to estimate relative vaccine effectiveness against becoming a confirmed case with Delta (5,689 cases) and/or Omicron (17,699 cases) in a population of 1.2 million people in the largest health board in Scotland, NHS ...
With the aggravation of population aging, glioma is becoming a more and more serious threat to human health. Therefore, early diagnosis and treatment is a crucial medical problem. Due to the invasiveness nature of glioma, it is very difficult to be completely removed in the surgery [3]. What...
The combination of molecular and pathway-based bioassays with unbiased transcriptome analysis has proved to be a valuable strategy in multicomponent activity assessment. Nevertheless, the selection of an appropriate experimental design, the cellular model system and the verification of findings in an iterat...
The Hedgehog (HH) signaling pathway is one of the fundamental signaling pathways that contributes to epidermal development, homeostasis, and repair, as well as to hair follicle development and follicle bulge stem cell maintenance. The HH pathway interacts with other signal transduction pathways, ...
Historically, FMRP is known to function as a translational suppressor. However, emerging data suggests that FMRP has both an agonistic and antagonistic role in regulating microRNA-mediated translational suppression. This bi-functional role is dependent on FMRP's interaction with the RNA helicase ...
Based on the important role of IDO1 in cancer immune tolerance and development, targeting IDO1 is becoming an attractive approach in cancer therapeutic development (Fig. 3b). Unlike cell-surface checkpoint receptor molecules that can be effectively targeted by antibody-based therapeutics, IDO1 and ...
Furthermore, current research on ageing biomarkers is also focusing in identifying molecules which also are able in giving clinical indications. On the other hand, biomarkers represent a hot topic and have the ability to change our life, if real prediction, on an individual basis, can be made ...
“You need that foundation,” he explains. “There is a movement afoot that believes an RN can go directly to earning a Doctor of Nursing Practice (DPN) and bypass the master’s degree.” According to the American Association of Colleges of Nursing (AACN), there are more than 250 schools...
ERK is distributed in various tissues and attended the regulation of cell proliferation and differentiation [27], whereas p38 is considered to regulate inflammation and apoptosis [28], thus becoming a target for the development of anti-inflammatory drugs. Our further tests confirmed that the ...