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Using natural language processing and the gene ontology to populate a structured pathway database Reading literature is one of the most time consuming tasks a busy scientist has to contend with. As the volume of literature continues to grow there is a n... D Dehoney,R Harte,Y Lu,... -...
Thus, we propose that replication-incompetent nucleoids are selectively eliminated by an adaptive mitochondria–endosomal quality control pathway that is prone to innate immune system activation, which might represent a therapeutic target to prevent mtDNA-mediated inflammation during viral infection and ...
To investigate the interplay between clay minerals and marine carbohydrates with marine heterotrophic bacteria, we first identified a mixture of clay minerals (palygorskite and nontronite, TableS1) that effectively sorbs dissolved acidic polysaccharides in synthetic seawater (Fig.S1). These organoclay comp...
Pericyte-myofibroblast transition (PMT) has been confirmed to contribute to renal fibrosis in several kidney diseases, and transforming growth factor-β1 (TGF-β1) is a well-known cytokine that drives PMT. However, the underlying mechanism has not been f
Interpretation of lists of genes or proteins with altered expression is a critical and time-consuming part of microarray and proteomics research, but relatively little attention has been paid to methods for extracting biological meaning from these output
Recent data indicates a lower proportion of chest injuries among pediatric trauma patients compared to past studies, yet these injuries still have a considerable negative impact, including disabilities and death. Rib fractures become progressively more frequent as individuals age, particularly around puberty...
Compared with mice, pigs are very similar to human in anatomy, physiology and genetics, so pig become the most valuable and ideal disease model animal in the research of life science and medical science (Lunney, 2007). Recently pigs are often used as experimental animals in endocrine, ...
After stimulation by LPS, the subcellular distribution of bbt- TICAM is unchanged, while bbtMyD88 become larger spots and still do not co-localize with bbtTICAM. (F) HsTICAM1 and HsMyD88 (human MyD88) do not co-stimulate the signal pathway, as is the case with the controls. The Hs...
Recently, immune checkpoint blockade (ICB) targeting the programmed cell death-1 (PD-1) or programmed cell death ligand-1 (PD-L1) axis, either alone or in combination with conventional chemotherapy, has become a new standard of care in NSCLC, leading to improvements in survival.1 Analyses of...