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To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Reprints and permissions About this article Cite this article Sant, V., Matthes, D., Mazal, H. et al. Lipidic folding pathway of α-Synuclein via a toxic oligomer. Nat Commun 16, 760 (2025). https:...
4a–f). Substrate unfolding by p97 was monitored by fusing I3 to mEos (forming I3mEos)33. mEos is a photoactivable protein that shifts its fluorescence emission from green to red upon the ultraviolet (UV)-induced breakage of a peptide backbone near the chromophore34. This prevents mEos ...
Raw data are available through the PCAWG data portal https://dcc.icgc.org/pcawg. Processed data from the PCAWG Networks and Pathways working groups as well as other PCAWG working groups are available on www.synapse.org at the Synapse links provided in this section. The source data underlying ...
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http://software.broadinstitute.org/gsea/msigdb/cards/GAURNIER_PSMD4_TARGETS. Tonoli C, et al. Type 1 diabetes-associated cognitive decline: a meta-analysis and update of the current literature. J Diabetes. 2014;6(6):499–513. Article PubMed Google Scholar Kandimalla R, Thirumala V, ...
Bionet. http://www.chip.org/~wbosl/Software/Bionet/bionet.html Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, Kim JY, Goumnerova LC, Black PM, Lau C, Allen JC, Zagzag D, Olson JM, Curran T, Wetmore C, Biegel JA, Poggio T, Mukherjee S, Rifkin R...
Program News Introducing the New Ron Brown Scholar Program Website: A Fresh Look, Same Transformative Mission Program News Joel Bervell: Inspiring the Next Generation Through “The Doctor Is In” Scholar Alumni News Hope Jackson Selected as Schwarzman Scholar ...
(SCs) through lateral inhibition rather than direct lineage changes154,155. This cascade reaction between DLL4-mediated NOTCH signaling and VEGFA-VEGFR2 signaling induces ECs near dominant TCs to maintain a high level of NOTCH signaling, inhibiting their differentiation into TCs198,199. NOTCH ...
enhancers that are normally constrained within insulated TADs are juxtaposed near constitutively repressed oncogenes by SVs, resulting in aberrant activation of the oncogenes39,40. Fig. 5: Tandem duplication involvingIHHalters chromatin structure and creates neo-loops betweenDIRC3super-enhancers andIHH....