The conserved nature of this dual behavior of Yki in damage response may reflect its proposed ancient function as a mediator of tissue damage repair.66 This decision-making process may lie at the heart of the choice each damaged cell must make between survival and repair or undergoing apoptosis...
Fuentes1,4, Wei Yang2,4, Victor G Da´vila-Roma´n1 and C Charles Gu*,2,3 Genome-wide association (GWA) studies of complex diseases including coronary heart disease (CHD) challenge investigators attempting to identify relevant genetic variants among hundreds of thousands of markers being ...
The proteins were heated at 45 to 69 °C under the same conditions using a heat block for 2 min. The supernatant was collected for western blotting (C). Diagram of the molecular mechanisms of CKN (D). Data are presented as mean ± SD (n = 3) and were analyzed by ANOVA ...
Functional activity of Factors VII, X, V, and II determines the extrinsic pathway which is thus measured by evaluating the PT. A comparative study of the variation in coagulation profile between different blood groups in ischemic heart disease patients and normal subjects In extrinsic pathway, cell...
Joint capsule fibrosis, a common complication of joint immobilization, is mainly characterized by abnormal collagen deposition. The present study aimed to investigate the effect of extracorporeal shock wave therapy (ESWT) on reduced collagen deposition in the joint capsule during immobilization-induced join...
This effect was blocked by the inhibition or knock-down of ERK1/2. The present study provides evidences of the neuroprotective effect of artemether unravelling its potential as a new therapeutic candidate for the prevention and treatment of stroke. Graphical abstract A schematic diagram of artemether...
Furthermore, knockout of p62 abrogates Tsg101-induced cardio-protective effects during I/R. Hence, our findings uncover a previously unrecognized role of Tsg101 in the regulation of p62/Keap1/Nrf2 signaling cascades and provide a new strategy for the treatment of ischemic heart disease. Graphical...
Extracellular vesicles (EVs) play an important role in human and bovine milk composition. According to excellent published studies, it also exerts various functions in the gut, bone, or immune system. However, the effects of milk-derived EVs on skeletal muscle growth and performance have yet to...
All open vascular surgical procedures were performed at the Division of Vascular Surgery and the Heart Center at Tampere University Hospital between 2006 and 200927. The study has been approved by the Ethics Committee of Pirkanmaa Hospital District and clinical investigation followed the principles of ...
data Jinying Zhao1, Yun Zhu1, Eric Boerwinkle2 and Momiao Xiong*,2 Although pathway analysis methods have been developed and successfully applied to association studies of common variants, the statistical methods for pathway-based association analysis of rare variants have not been well developed....