Depending on size and properties, inhaled nanomaterials can enter the lung and interact with the respiratory wall. While larger materials are deposited in the conducting airways, smaller ones reach the peripheral gas-exchange region and may pass the air鈥揵lood tissue barrier to enter the systemic ...
In the future, we will use a mouse model of inhaled cadmium exposure to further clarify the mechanism of lung injury induced by cadmium exposure. Conclusion Taken together, our data suggest that upon mitochondrial stress in AECs caused by cadmium exposure, mtDNA leakage into the cytoplasm ...
Since hemoglobin in erythrocytes in the lung capillary is separated from alveolar air by pneumocytes, vascular endothelium, the blood plasma layer and the erythrocyte membrane, inhaled oxygen molecules diffuse from alveolar air through cell membranes and cytosol to reach the hemoglobin molecules. The ...
AHR is the most important pathological feature of asthma, which distinguishes it from other airway inflammatory diseases. AHR was assessed by measuring Penh value in OVA-LPS sensitized/challenged mice exposed to the increasing concentrations of inhaled MCh. In our study, AHR significantly increased in...
The impact of environmentally-induced chemical changes in RNA has been fairly unexplored. Air pollution induces oxidative modifications such as 8-oxo-7,8-dihydroguanine (8-oxoG) in RNAs of lung cells, which could be associated with premature lung dysfunc
In contrast, CO-dependent expression of Sesn2 mRNA in CO-treated Ire1α-/- and Atf6-/- hepatocytes was similar to that of the corresponding WT cells (Supplementary Fig. 2B and C). Furthermore, we determined the effect of inhaled CO on Sesn2 upregulation in the liver of eIF2αA/A ...
The ability of a virus to cluster is important for its infectivity and maturation54,55,56,57. Previously, anesthetics were shown to perturb clustering in two ways. First, inhaled anesthetics tend to increase the apparent size and number of clusters, as observed using super-resolution imaging and...
Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction Ambient air PM(2.5) (particulate matter less than 2.5 mum in diameter) has been associated with cardiovascular diseases (CVDs), but the underlying mechanis... C Quan,Q ...
those who used inhaled or oral glucocorticoids for 3 months before the operation, those who received chemotherapy or radiotherapy at any time before the absence of tumor- or pneumonia-free lung tissue specimens, and those who used biomass fuel and had history of occupational exposure were excluded...
In addition, the production of OVA-specific IgG2a and IFN-γ-inducible protein (IP)-10 was also impaired in the absence of IL-13, but not of IL-4. Lung-targeted IFN-γ over-expression in the air- ways enhanced methacholine AHR and non-eosino- philic inflammation; in addition, these ...