The airway epithelium represents the main barrier between inhaled air and the tissues of the respiratory tract and is therefore an important point of contact with xenobiotic substances into the human body. Several studies have recently shown that in vitro models of the airway grown at an air-...
In the respiratory system of COPD patients, we see the obvious signs of airflow inhibition: wall remodeling and mucus formation. Among them, distorted growth and hypertrophy of airway smooth muscle cells (ASMCs) is one of the most important features of COPD airway remodelling. One of the ...
In the future, we will use a mouse model of inhaled cadmium exposure to further clarify the mechanism of lung injury induced by cadmium exposure. Conclusion Taken together, our data suggest that upon mitochondrial stress in AECs caused by cadmium exposure, mtDNA leakage into the cytoplasm ...
In addition, the production of OVA-specific IgG2a and IFN-γ-inducible protein (IP)-10 was also impaired in the absence of IL-13, but not of IL-4. Lung-targeted IFN-γ over-expression in the air- ways enhanced methacholine AHR and non-eosino- philic inflammation; in addition, these ...
As the mice inhaled increasing concentrations of methacholine(Macklin, Shanghai, China) ranging from 0 to 50 mg/ml (with intermediate doses of 6.25, 12.5, and 25 mg/ml), real-time measurements of inspiratory resistance (RI) were conducted and documented for the assessment of AHR. 2.4....
The ability of a virus to cluster is important for its infectivity and maturation54,55,56,57. Previously, anesthetics were shown to perturb clustering in two ways. First, inhaled anesthetics tend to increase the apparent size and number of clusters, as observed using super-resolution imaging and...
(F) Hepatic expression of SIRT1, acetylated-p65, cleaved-caspase-3 and p65 were evaluated in IR lobes from air- and CO-inhaled mice by immunoblotting.β-Actin was used as an internal control. (G) SIRT1 mRNA expression was as detected by quantitative RT-PCR in liver tissue. (H) ...
PM2.5 is easily inhaled into the respiratory tract and accumulated in lung alveoli, where the toxic particles may result in both structural damage and lung function impairment. A previous study has shown that short-term exposure to high ambient air pollution increases airway inflammation and daily ...
A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperrespon- siveness and remodeling by matrix metalloproteinases and cytokines modulation in a mouse model of asthma. Biochem Pharmacol. 2008; 75(2):514–526. 21. Ikeda N, Hayashi A, Iwasaki K, et al. ...
An intravenous (IV) set system comprising a primary IV set defining a primary flow line of the IV set system. The primary flow line can include multiple access points along its length and feeds to a merging fluid pathway proximate to the distal terminus of the primary IV set. At least one...