Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeos
By researching with helmet cooling, the feasibility and effectiveness of the blood perfusion scheme had been verified. By comparing aided by the calculation results predicated on Pennes equation, the rationality of the model constructed in this study had been validated. This model can non-intrusively...
- 《Journal of Cerebral Blood Flow & Metabolism Official Journal of the International Society of Cerebral Blood Flow & Metabolism》 被引量: 104发表: 1994年 Kinetic steps for alpha-helix formation The kinetics of alpha-helix formation in polyalanine and polyglycine eicosamers (20-mers) were ...
This vascular dysfunction results in altered capillary architecture with reduced vessel density, a hallmark of SSc, causing decreased capillary blood flow and tissue hypoxia25. Clinically, these microvascular changes underlie painful digital ulcerations, pulmonary arterial hypertension, gastric vascular ...
They found that APL is almost the same (about 3.2) for all 43 organisms studied. This means that most of the metabolites can be converted to each other in about three steps. These results are surprising, and in fact unexpected, in view of the often long pathways for the synthesis of ...
Kuntz said he knows of a few practices that are large enough to develop their own pathways, such as Moffitt Cancer Center in Tampa, Florida, but he cautioned that the work “is not for the faint of heart.”“While the building (of pathways) is very, very challenging, the mainten...
modulators of tubular glomerular responses in the kidney, which influence both the renal blood stream and the quantity of oxygen delivered [190]. In contrast, in diabetic nephropathy, alterations in extramural ATP via type 2 purinergic receptors already occur in the early stages of the disease, ...
Blood samples of mice were collected, and platelet-rich plasma was prepared for next analyses including platelet aggregation test, enzyme-linked immunosorbent assay (ELISA) to measure intraplatelet serotonin, and flow cytometry analysis with specific antibodies to label corresponding targets on platelets....
. The relative mRNA levels of each gene were calculated by using the 2−ΔΔCt method. Table 2 Sequences of qRT-PCR primers. Full size table Immunofluorescence assay The experimental operation steps of immunofluorescence were as follows. Dewaxing paraffin sections to water, circle, serum ...
Persistent endothelial injury promotes maladaptive responses by favoring the release of factors leading to perturbation in vascular homeostasis and tissue architecture. Caspase-3 dependent death of microvascular endothelial cells leads to the release of