摘要: Framing her own story of staggering loss and soaring hope with the biblical story of Job, Guthrie takes her fellow sufferers by the hand and guides them on a pathway through pain straight to the heart of God.出版时间: January 2007 ...
A digital approach to the care of patients with heart failure, developed by Boehringer Ingelheim and ORCHA, will be rolled out in the northwest of the UK by a primary care group. Widnes Primary Care Network, which is part of NHS Cheshire and Merseyside, said the new initiative will help ...
Kuntz said the companies differ in the ways they develop their pathways, how transparent their processes are, the number of diseases they cover, the pathways’ levels of detail, how well they support practices, and the number of choices at the end of each pathway. Kuntz said he knows...
Autophagy is a dynamic circulatory system that occurs in all eukaryotic cells. Cytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. This provides energy and macromolecular precursors for cell renewal and homeos
This vascular dysfunction results in altered capillary architecture with reduced vessel density, a hallmark of SSc, causing decreased capillary blood flow and tissue hypoxia25. Clinically, these microvascular changes underlie painful digital ulcerations, pulmonary arterial hypertension, gastric vascular ...
They found that APL is almost the same (about 3.2) for all 43 organisms studied. This means that most of the metabolites can be converted to each other in about three steps. These results are surprising, and in fact unexpected, in view of the often long pathways for the synthesis of ...
modulators of tubular glomerular responses in the kidney, which influence both the renal blood stream and the quantity of oxygen delivered [190]. In contrast, in diabetic nephropathy, alterations in extramural ATP via type 2 purinergic receptors already occur in the early stages of the disease, ...
Dietary nitrate (found in green leafy vegetables, such as rocket, and in beetroot) is now recognized to be an important source of nitric oxide (NO), via the nitrate–nitrite–NO pathway. Dietary nitrate confers several cardiovascular beneficial effects on blood pressure, platelets, endothelial func...
The broad availability of blood-based biomarkers will facilitate a critical step towards a cost-, resource- and time-effective multi-step diagnostic work-up and accelerate the re-engineering of drug Research & Development (R&D) pipelines, from proof of pharmacology to clinical trial design. The ...
Mitochondrial clearance progresses through a well-documented series of steps including nuclear aggregation before complete removal65; thus, cells displaying nuclear aggregation or lack of mitochondria were scored as 'cleared.' Endosomal and autophagic vesicles in cells were quantified by counting the number...