The blood purifying pathway fixator has the advantages that the structure is simple, the pathway catheter is firmly fixed when blood of a patient is purified, the operation is simple and convenient, time and labor are saved, and the work difficulty of the medical staff is reduced.邓秀芝...
Inhibition of clotting After the activation of the blood-clotting system, the active enzymes must be turned off and the clotting process contained locally to the area of tissue injury. The details of the regulation of blood coagulation remain obscure, but it is clear that a series of blood pro...
Abnormal amplification and recruitment of blood cells lead to hematologic malignancies. The normal actions of the JAK/STAT pathway rely on various components. Thus, basic molecular alterations, such as those caused by gain-of-function mutations in different components (JAK, STAT) and extensive express...
Clinically, increased serum urate levels are indicative of pregnancy-induced hypertension (PIH). However, how urate is handled in the placenta is still largely unknown. In this study, we compared maternal serum urate levels with those of umbilical cord blood and investigated urate transport ...
Transcriptome analysis in combination with pathway-focused bioassays is suggested to be a helpful approach for gaining deeper insights into the complex mechanisms of action of herbal multicomponent preparations in living cells. The polyherbalism based concept of Tibetan and Ayurvedic medicine considers thera...
Increased IL-6 blood levels in melanoma patients correlate with disease progression and lower response to chemotherapy58. Importantly, studies proposed OSMR, an IL-6-type cytokine receptor, to play a role in the prevention of melanoma progression59, and as a novel potential target in other cancer...
Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumo
Although the mechanisms by which JAK/STAT pathway is regulated theoretically, look simple; the bimolecular consequences of signaling activation are complicated. Because numerous interactions may occur with other signaling pathways and molecules (crosstalk) [34]. JAK-STAT pathway has a critical role in ...
Amyloid-β 1–42 (Aβ42) oligomers are synaptotoxic for excitatory cortical and hippocampal neurons and might play a role in early stages of Alzheimer’s disease (AD) progression. Recent results suggested that Aβ42 oligomers trigger activation of AMP-activated kinase (AMPK), and its activation...
Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The mechanisms of exosome biogenesis remain poorly explored. Here we identify that RAB31 mark