When it comes to a meaningful life, we might think of love, happiness and health. A life filled with meaning is what most of us want for ourselves. Then, what makes a meaningful life? Many researchers agree that a meaningful life comes down to three factors: having long-term goals, be...
The linkage between REMIND and MAgPIE is bi-directional (iterative soft coupling), the linkages to the downstream models for further SDG indicators are one-directional. The most relevant variables passed between models are specified next to the arrows. The colour-coding of the additional models ...
Next, we targeted fluorescently labeled PV+ interneurons in acute slices of adult mouse mPFC from PV-Cre::TdTomato mice [69, 70] to test for functional NMDARs electrophysiologically. Given that NMDARs accumulate synaptically and extrasynaptically, we began by uncaging glutamate (MNI-Glu; bath...
BACKGROUND: Gene set analysis (GSA) is a widely used strategy for gene expression data analysis based on pathway knowledge. GSA focuses on sets of related ... W Luo,MS Friedman,K Shedden,... - 《Bmc Bioinformatics》 被引量: 798发表: 2009年 GAGE: generally applicable gene set enrichment...
It’s somewhat controversial, but we’re getting used to the idea that drugs could get approved based on shorter-term outcomes or end points like disease-free survival [DFS] instead of waiting for OS. I know that’s been a sticking point with a lot of people about adjuvant osimertinib [...
A UN Framework for the Immediate Socio-Economic Response to COVID-19 United Nations (UN), New York, USA (2020), p. 51 Google Scholar UNEP, 2020 I.L.R.I. UNEP Preventing the Next Pandemic: Zoonotic Diseases and How to Break the Chain of Transmission United Nations Environment Programme ...
The most prominent such mechanism is stimulus-induced long-term potentiation of synaptic connectivity7, an energy-demanding process that involves extensive biochemical and morphological adaptations at all levels of neuronal function8,9. There is also evidence for contributions of pre-existing developmental...
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At present, in many countries, it is rare for user feedback to be sought (Nove et al., 2014a). Foundation 7: First-level midwifery care close to the woman and her family, with seamless transfer to next-level care if needed, is fully in line with the vision of universal health care...
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