Recently, after a period of neglect, there has been a revival of interest in malaria as a subject for clinical and laboratory research. In this article, Rodney Phillips and David Warrell review aspects of that work and attempt to unravel the mysteries of the pathophysiology of severe malaria ...
In humans, severe falciparum malaria disturbs the function of many tissues and organs. It is unlikely that a single pathophysiological process is responsible for the diverse effects of the infection. However, there is increasing evidence that impairment of local blood flow resulting from sticking of ...
BackgroundDespite the programmes of malaria control the incidence of mortality fromsevere malaria (SM) continues to rise. This is mainly attributable to the factthat the pathophysiological mechanisms are still not clearly defined.ObjectivesThis project investigated the endocrine and paracrine aspects of th...
The infection of the red cells by malaria parasites, particularlyP. falciparum, results in progressive and dramatic structural, biochemical, and mechanical modifications of the red cells that can worsen into life-threatening complications of malaria. While the vast majority of severe malaria and related...
A lot of research has been focussed on the immunopathogenesis of the disease, establishing the role of cytokines and other mediators like nitric oxide. This short review, however, will focus on the role of a compromised microcirculation in the pathogenesis of severe malaria. The two mechanisms ...
Presents a commentary on an in-vitro model which offers insight into the pathophysiology of severe malaria. How Plasmodium faciparum is the cause of 3 mill... - 《Lancet》 被引量: 0发表: 2004年 Simulation of Primary Haemostasis in vitro Primary haemostasis was simulated in vitro under standard...
Despite our improved understanding of the pathophysiology of severe malaria, major changes in clinical management have not been forthcoming. However, in th... E Mike - 《Transactions of the Royal Society of Tropical Medicine & Hygiene》 被引量: 998发表: 2000年 Severe Sepsis and Septic Shock. ...
Describe the pathophysiology of sepsis. What are some common diseases that cause a secondary immunodeficiency? What is the etiology of malaria? What is the pathophysiology of septic shock? What is the etiology of tuberculosis? What is a lytic infection? What is the pathogenesis of the Ebola virus...
Pathologically, there was extensive acute edema, hemorrhage, and exudation to the point of consolidation. Group II had less severe hypoxemia which improved moderately but slowly in response to PEEP and shunt increased with decrease in FIO2 indicating diffusion disturbances or severe ventilation-perfusion...
The pathophysiologic and prognostic significance of acidosis in severe adult malaria. OBJECTIVE: To investigate the pathophysiology and prognostic significance of acidosis in severe adult malaria. DESIGN: Cohort study. SETTING: The intensive... NPJ Day,NH Phu,NTH Mai,... - 《Critical Care Medicine...