musculo-skeletal manifestations.\nThe first part is devoted to the disease's pathophysiology (differentiating hemophilia A and B), genetics, pharmacotherapy – including replacement and non-replacement therapy – and gene therapy, as well as quality of life issues – also related to hemophilia ...
Hairy tongue (lingua villosa) is a commonly observed condition of defective desquamation of the filiform papillae that results from a variety of precipitating factors. The condition is most frequently referred to as black hairy tongue (lingua villosa nig
These pathogenic processes interact with each other and ultimately lead to a fibrotic joint and the disabling condition characteristic of hemophilic arthropathy. Keywords: hemophilia; hemarthrosis; hemophilic arthropathy; synovitis 1. Introduction Hemophilia A and B are X-linked congenital bleeding disorders...
Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is frequently complicated by thrombosis. In some cases of severe COVID-19, fibrinolysis may be markedly enhanced within a few days, resulting in fatal bleeding. In the treatment ...
Spontaneous joint and extensive muscle bleeding, characteristic of patients with severe hemophilia, are uncommon in patients with severe FXIII deficiency Physical findings Physical findings depend on the site at which bleeding develops and include the following: Bleeding from the umbilical cord after birth...
What do multiple sclerosis and ALS (amyotrophic lateral sclerosis) have in common? a. They both impair nerve function in the peripheral nervous system. b. They both are more common in young men than in young women. c. They both impair the initiation of ac...
Hemophilia is caused by mutations in either the factor VIII (FVIII) or factor IX (FIX) genes, classified as hemophilia A and hemophilia B, respectively. Both genes are located on the X chromosome, causing the classic X-linked inheritance of these conditions. The comprehensive incidence of ...
Areas covered: This article is a narrative review of the pathophysiology of the disturbed angiogenesis in hemophilia and the potential role of antiangiogenic drugs in nonhemophilia patients Expert commentary: Antiangiogenic drugs could be helpful in the future for the treatment of hemarthroses in ...
Pathophysiology of the disturbed angiogenesis in hemophiliaHemophiliaangiogenesisantiangiogenic drugshemarthrosishemophilic arthropathyIntroduction: It has been reported an increase ofdoi:10.1080/17474086.2016.1234933CarlosLaRodriguez-MerchanLaE.LaExpert review of hematology...
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