Hemophilia is caused by mutations in either the factor VIII (FVIII) or factor IX (FIX) genes, classified as hemophilia A and hemophilia B, respectively. Both genes are located on the X chromosome, causing the classic X-linked inheritance of these conditions. The comprehensive incidence of ...
Hemophilia B is caused by a variety of defects in the F9 gene. [1] As this gene is carried on the X chromosome, the disease usually manifests in males and is transmitted by females who carry the causative mutation on one of their X chromosomes. Spontaneous mutation and acquired immunologic...
Haemophilia the Official Journal of the World Federation of HemophiliaLacroix-Desmazes S, Misra N, Bayry J, Artaud C, Drayton B, Kaveri V, Kazatchkine MD. Pathophysiology of inhibitors to factor VIII in patients with haemophilia A. Haemophilia 2002; 8:273-279....
Hemophilia A C. Thrombocytosis D. Penia Correct Answer A. Von Willebrand's disease Explanationvon Willebrand's disease is the correct answer because it is a genetic disorder that results in defects in platelet adhesion. This disease is caused by a deficiency or dysfunction of von Willebrand...
TEs cause a variety of diseases in humans including Hemophilia type A by disrupting normal gene function; and cancers and developmental diseases by causing genomic rearrangements [26]. Despite these associations, attempts to measure TE expression levels in healthy control and disease tissue samples usin...
What do multiple sclerosis and ALS (amyotrophic lateral sclerosis) have in common? a. They both impair nerve function in the peripheral nervous system. b. They both are more common in young men than in young women. c. They both impair the initiation of ac...
Areas covered: This article is a narrative review of the pathophysiology of the disturbed angiogenesis in hemophilia and the potential role of antiangiogenic drugs in nonhemophilia patients Expert commentary: Antiangiogenic drugs could be helpful in the future for the treatment of hemarthroses in ...
Pathophysiology of the disturbed angiogenesis in hemophiliaHemophiliaangiogenesisantiangiogenic drugshemarthrosishemophilic arthropathyIntroduction: It has been reported an increase ofdoi:10.1080/17474086.2016.1234933CarlosLaRodriguez-MerchanLaE.LaExpert review of hematology...
Inoue K, Hifumi T, Kiriu N, Kanemura T, Okada I, Inoue J, et al. Acute coagulopathy after multiple blunt injuries in a case of hemophilia A-consideration for pathophysiology of coagulopathy. Am J Emerg Med. 2017;35(1):194.e1-194.e3....
This increase could be the consequence of different factors; firstly, improvements in diagnostic testing and the spreading acknowledgment of a solid link between cancer and venous thrombotic events; secondly, it could be the effect of multiple novel treatments with both direct and indirect iatrogenic ...