Becker and Kiener initially described Becker muscular dystrophy (BMD) in 1955. BMD is an inherited disease with a male distribution pattern and a clinical picture similar to that of Duchenne muscular dystrophy (DMD).
The X-linked neuromuscular disorder, Duchenne muscular dystrophy (DMD), is one of the most common fatal genetic disorders diagnosed in childhood. It is caused by frameshift mutations in theDMDgene that prevent the body-wide translation of its protein product, dystrophin. Although characterised by th...
If patients develop significant scoliosis, which generally occurs after they stop walking, early stabilization of the spine should be considered. Next: Pathophysiology What to Read Next on Medscape Related Conditions and Diseases Congenital Muscular Dystrophy Becker Muscular Dystrophy Emery-Dreifuss ...
Neuropathophysiology of Duchenne muscular dystrophy: involvement of the dystrophin isoform Dp71 in cell migration and proliferation Duchenne and Becker muscular dystrophy (DMD/BMD) are caused by mutations in the dystrophin gene and characterized by severe and mild progressive muscle was... Ash,A.,Mach...
Becker's muscular dystrophy is an X-linked hereditary disorder characterised by progressive muscle weakness and possible cardiac disease. Cardiac involvement is assumed to be rare in young patients. Early diagnosis could lead to earlier treatment at an infra-clinical stage of the disease. The object...
et al. The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion. Am. J. Hum. Genet. 45, 498–506 (1989). CAS PubMed PubMed Central Google Scholar Im, W. B. et al. Differential expression of dystrophin isoforms in strains of mdx ...
Duchenne muscular dystrophy is a progressive, fatal, X-linked genetic disorder of chronic inflammation involving dystrophin gene mutations. OS is a contributor to the pathogenesis of Duchenne muscular dystrophy [27]. The muscle wasting associated with Duchenne muscular dystrophy involves the nuclear factor...
Even if high efficiency of these therapies is achieved in skeletal muscle, the phenotypic outcome in DMD patients may resemble the disease characteristics of Becker muscular dystrophy or X-linked dilated cardiomyopathy (XLCM) due to the reduced expression and/or truncation of dystrophin. Patients ...