Clinically, chronic heart failure (CHF) is a syndrome of dyspnoea, fatigue or exercise intolerance due to systolic or diastolic cardiac dysfunction.It is associated with a complex pattern of neurohormonal activation that results in fluid retention and vasoconstriction.While dyspnoea and fatigue are the...
慢性肾功能衰竭(chronic renal failure,CRF):各种慢性肾脏疾病,随病情恶化,肾单位进行性破坏,以致残存肾单位不足以充分排出代谢废物和维持内环境恒定,进而发生泌尿功能障碍和内环境紊乱,包括代谢废物和毒物的潴留,水。电解质和酸碱平衡紊乱,并伴有一系列临床症状的病理过程,称为~ 氮质血症(azotemia)...
Chronic heart failure (CHF) is a complex clinical syndrome that results from the functional or structural heart disorder impairing ventricular filling or ejection of blood to the systemic circulation. CHF is associated with underlying cellular and molecular changes in the myocardial cells, subsequently ...
However, the hemodynamic model is still relevant for patients in the hospital with decompensated heart failure, where positive inotropic drugs and vasodilators are still widely used. The modern treatment of chronic heart failure is now largely based on the neurohormonal hypothesis, which states that ...
Purchase Pathophysiology, Risk Factors, and Management of Chronic Heart Failure - 1st Edition. Print Book & E-Book. ISBN 9780128229729, 9780128231111
functionsoftheheart Cardiacoutput(CO)=heartrate(HR)xstrokevol.(SV)-changesoftheheartrate-changesofstrokevolume •ControlofHR:-autonomicnervoussystem -hormonal(humoral)control•ControlofSV:-preload -contractility-afterload Adaptivemechanismsofthehearttoincreasedload •Frank-Starlingmechanism •Ventricular...
Basic mechanisms of chronic heart failure are reviewed. A central theme that cuts all the way through this review is that chronic heart failure is a problem of failing complexity, rather than a problem of the failure of a single unit (e.g., cell type) or processes (e.g., contractility)...
Impact of adenosine receptor signaling and metabolism on pathophysiology in patients with chronic heart failure. Hypertens Res. 2007;30(9):781-7.Asakura M, Asanuma H, Kim J, Liao Y, Nakamaru K, Fujita M, Komamura K, Isomura T, Furukawa H, Tomoike H, Kitakaze M. Impact of adenosine ...
The pathophysiologic mechanisms leading to HF are complex and encompass hemodynamic alterations and neurohormonal changes that contribute to the chronic, progressive nature of the disease. This chapter reviews the pathophysiologic mechanisms that underlie the clinical manifestations of the HF syndrome, ...
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