Partin''s tables accurately estimated OC disease, EPE and seminal vesical invasion with the observed outcome plot overlying the ideal correlation curve. More patients in our cohort had OC disease than was predicted by the MSKCC nomogram; fewer patients had EPE that was predicted by the MSKCC ...
Recent evidence suggested that both early-onset PSDS and right basal ganglia infarction were predictive of future PSDS at chronic stage of stroke [11]. However, the direct association between lesion location and early-onset PSDS remains elusive. There is a growing recognition that some ...
Mitochondrial pathology worsens with disease progression In addition to assessing Braak stage 3/4 brains, we assessed late Braak stage 6 PD brain (compared to con- trols) for two selected regions—the frontal cortex and the putamen, shown in the PCA plot (Fig. 5). This enabled us to ...
Altered exon inclusion within circRNA isoforms leads to dysregulated activities of miRNAs and RBPs during AD progression.AVolcano plot of global circRNA isoform switching due to alternative inclusion of internal exons was identified by A-tailing/CARP in 7-month 5xFAD mice. Isoform switching events ar...
The values were normalized to the NSC stage activity for each line and represent means ± s.e.m.; ASD (n = 8; 16 technical replicates total), control (n = 5; 10 technical replicates total); n refers to biologically independent subject lines. f, Representative confocal ...
The primary endpoint of the NACATRINE trial was pCR, which was defined as pathological stage ypT0/Tis ypN0 at the time of definitive surgery. The secondary endpoints were OS and DFS, defined as the time from treatment to death and the time from randomization to disease recurrence, respectively...
5B). Anle138b is already known to have an effect on glucose metabolism, restoring normal metabolism in a mouse model of late-stage AD [7] and also halting AD progression [33]; therefore, our results are consistent with previous knowledge in this regard. Additionally, ELK1 was recovered, ...
Bar plot values correspond to quantified average of blue highlighted regions. c Baseline low gamma power spectra values before tau seeding injection in 6-month-old APP-KI animals, across multiple brain regions. Error bars are standard error of mean. Asterisks indicate significant comparisons (p ...
plot showing the Spearman correlation coefficients between beta power during NREM sleep and the PSQI when analyzing the high/low beta band and the NREM 1/2/3 stage of sleep. Bars and items with Spearman correlationP < 0.05 are colored in orange and highlighted in bold, respectively.Pfor...
Depending on site and stage, these patients are treated with definitive (concurrent chemo)radiotherapy [(C)RT] or extensive surgery combined with free or pedicled flap reconstuction followed by adjuvant (C)RT. Still, 5-year overall survival after surgery is only 50%2,3, with patients bearing...